ACC2 Catalyzes the ATP-dependent carboxylation of acetyl-CoA to malonyl-CoA. Carries out three functions: biotin carboxyl carrier protein, biotin carboxylase and carboxyltransferase. Involved in inhibition of fatty acid and glucose oxidation and enhancement of fat storage. May play a role in regulation of mitochondrial fatty acid oxidation through malonyl-CoA-dependent inhibition of carnitine palmitoyltransferase 1. Widely expressed with highest levels in heart, skeletal muscle, liver, adipose tissue, mammary gland, adrenal gland and colon (PubMed:9099716). Isoform 3 is expressed in skeletal muscle, adipose tissue and liver (at protein level) (PubMed:19190759). Isoform 3 is detected at high levels in adipose tissue with lower levels in heart, liver, skeletal muscle and testis (PubMed:19190759). 3 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Carbohydrate Metabolism - propanoate; Carbohydrate Metabolism - pyruvate; EC; EC; Ligase; Lipid Metabolism - fatty acid biosynthesis; Mitochondrial
Chromosomal Location of rat Ortholog: 12q16
Cellular Component:  mitochondrion; nucleus
Molecular Function:  acetyl-CoA carboxylase activity; ATP binding; biotin binding; identical protein binding; metal ion binding
Biological Process:  acetyl-CoA metabolic process; energy homeostasis; fatty acid biosynthetic process; malonyl-CoA biosynthetic process; negative regulation of catalytic activity; negative regulation of fatty acid beta-oxidation; negative regulation of fatty acid oxidation; negative regulation of gene expression; negative regulation of lipid catabolic process; positive regulation of heart growth; positive regulation of lipid storage; protein homotetramerization; regulation of glucose metabolic process; response to drug; response to nutrient levels; response to organic cyclic compound
Reference #:  O70151 (UniProtKB)
Alt. Names/Synonyms: Acacb; Acc2; Acetyl-CoA carboxylase; acetyl-Coenzyme A carboxylase 2; acetyl-Coenzyme A carboxylase beta
Gene Symbols: Acacb
Molecular weight: 276,100 Da
Basal Isoelectric point: 5.84  Predict pI for various phosphorylation states
Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology® Total Proteins
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Protein Structure Not Found.

Cross-references to other databases:  STRING  |  Reactome  |  BioGPS  |  Pfam  |  ENZYME  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene