ACC2 a subunit of acetyl-CoA carboxylase (ACC), a multifunctional enzyme system. Catalyzes the carboxylation of acetyl-CoA to malonyl-CoA, the rate-limiting step in fatty acid synthesis. Activity is increased by oligomerization. Activated by citrate. Citrate and MID1IP1 promote oligomerization. Inhibited by malonyl-CoA. ACC1 is the predominant form expressed in liver, adipocyte and mammary gland. Phosphorylation by AMPK or PKA inhibits the enzymatic activity of ACC. ACC2 is the major isoform in skeletal muscle and heart. Phosphorylation regulates its activity. Two isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: Carbohydrate Metabolism - propanoate; Carbohydrate Metabolism - pyruvate; EC; EC; Ligase; Lipid Metabolism - fatty acid biosynthesis; Mitochondrial
Chromosomal Location of Human Ortholog: 12q16
Cellular Component:  mitochondrion; nucleus
Molecular Function:  acetyl-CoA carboxylase activity; ATP binding; biotin binding; identical protein binding; metal ion binding
Biological Process:  acetyl-CoA metabolic process; energy homeostasis; fatty acid biosynthetic process; malonyl-CoA biosynthetic process; negative regulation of catalytic activity; negative regulation of fatty acid beta-oxidation; negative regulation of fatty acid oxidation; negative regulation of gene expression; negative regulation of lipid catabolic process; positive regulation of heart growth; positive regulation of lipid storage; protein homotetramerization; regulation of glucose metabolic process; response to drug; response to nutrient levels; response to organic cyclic compound
Reference #:  O70151 (UniProtKB)
Alt. Names/Synonyms: Acacb; Acc2; Acetyl-CoA carboxylase; acetyl-Coenzyme A carboxylase 2; acetyl-Coenzyme A carboxylase beta
Gene Symbols: Acacb
Molecular weight: 276,100 Da
Basal Isoelectric point: 5.84  Predict pI for various phosphorylation states
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Protein Structure Not Found.

Cross-references to other databases:  STRING  |  Reactome  |  BioGPS  |  Pfam  |  ENZYME  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene