MEKK2 Component of a protein kinase signal transduction cascade. Regulates the JNK and ERK5 pathways by phosphorylating and activating MAP2K5 and MAP2K7. Plays a role in caveolae kiss-and-run dynamics. Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily. Note: This description may include information from UniProtKB.
Protein type: EC 2.7.11.25; Kinase, protein; Protein kinase, STE; Protein kinase, Ser/Thr (non-receptor); STE group; STE11 family
Chromosomal Location of Human Ortholog: 18|18 B1
Cellular Component:  cytoplasm; cytosol; nucleoplasm; nucleus
Molecular Function:  ATP binding; kinase activity; MAP kinase kinase kinase activity; metal ion binding; nucleotide binding; protein binding; protein kinase activity; protein kinase binding; protein serine/threonine kinase activity; transferase activity
Biological Process:  activation of protein kinase activity; phosphorylation; positive regulation of transcription, DNA-templated; protein phosphorylation; signal transduction by protein phosphorylation; stress-activated protein kinase signaling cascade
Reference #:  Q61083 (UniProtKB)
Alt. Names/Synonyms: 9630061B06Rik; AI585793; M3K2; MAP/ERK kinase kinase 2; Map3k2; MAPK/ERK kinase kinase 2; MEK kinase 2; MEKK 2; Mekk2; Mekk2b; mitogen activated protein kinase kinase kinase 2; Mitogen-activated protein kinase kinase kinase 2; protein kinase MEKK2b
Gene Symbols: Map3k2
Molecular weight: 69,574 Da
Basal Isoelectric point: 8.62  Predict pI for various phosphorylation states
CST Pathways:  Actin Dynamics  |  B Cell Receptor Signaling  |  Regulation of P38 MAPKs  |  SAPK/JNK Signaling Cascades
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MEKK2

Protein Structure Not Found.


Cross-references to other databases:  STRING  |  BioGPS  |  KinBase  |  Pfam  |  ENZYME  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  Ensembl Protein