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MEKK1
Component of a protein kinase signal transduction cascade. Activates the ERK and JNK kinase pathways by phosphorylation of MAP2K1 and MAP2K4. May phosphorylate the MAPK8/JNK1 kinase. Activates CHUK and IKBKB, the central protein kinases of the NF-kappa-B pathway. Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily. Note: This description may include information from UniProtKB.
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| Protein type: EC 2.7.11.25; Kinase, protein; Ligase; MEKK1 subfamily; Protein kinase, STE; Protein kinase, Ser/Thr (non-receptor); STE group; STE11 family; Ubiquitin conjugating system; Ubiquitin ligase |
| Chromosomal Location of rat Ortholog: 2q14 |
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Cellular Component:
cellular anatomical entity; cytoplasm; filamentous actin; membrane
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Molecular Function:
ATP binding; cytoskeletal protein binding; JUN kinase binding; JUN kinase kinase kinase activity; MAP kinase kinase activity; MAP kinase kinase kinase activity; mitogen-activated protein kinase binding; mitogen-activated protein kinase kinase binding; protein binding; protein kinase activity; protein kinase binding; protein serine kinase activity; protein serine/threonine kinase activity; protein-containing complex binding; sphingolipid binding; ubiquitin-protein transferase activity; zinc ion binding
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Biological Process:
apoptotic mitochondrial changes; camera-type eye development; cellular response to mechanical stimulus; epithelial cell morphogenesis; eyelid development in camera-type eye; JNK cascade; MAPK cascade; morphogenesis of an epithelial sheet; negative regulation of actin filament bundle assembly; peptidyl-serine phosphorylation; positive regulation of actin filament polymerization; positive regulation of apoptotic process; positive regulation of canonical Wnt signaling pathway; positive regulation of DNA-templated transcription; positive regulation of JNK cascade; positive regulation of JUN kinase activity; positive regulation of MAP kinase activity; positive regulation of MAPK cascade; positive regulation of transcription by RNA polymerase II; positive regulation of viral transcription; protein autophosphorylation; protein phosphorylation; protein polyubiquitination; regulation of cell migration; transforming growth factor beta receptor signaling pathway; ubiquitin-dependent protein catabolic process; wound healing
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Reference #:
Q62925
(UniProtKB)
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Alt. Names/Synonyms: M3K1; Map3k1; MAPK/ERK kinase kinase 1; MEK kinase 1; Mekk; MEKK 1; Mekk1; mitogen activated protein kinase kinase kinase 1; Mitogen-activated protein kinase kinase kinase 1
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Gene Symbols: Map3k1
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Molecular weight:
161,315 Da
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Basal Isoelectric point:
8.03
Predict pI for various phosphorylation states
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CST Pathways:
Actin Dynamics
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B Cell Receptor Signaling
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ErbB/HER Signaling
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Growth And Differentiation Control by MAPKs
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Regulation of P38 MAPKs
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SAPK/JNK Signaling Cascades
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T Cell Receptor Signaling
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TGF-ß Signaling
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Toll-Like Receptor Signaling
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