MEKK1 Component of a protein kinase signal transduction cascade. Activates the ERK and JNK kinase pathways by phosphorylation of MAP2K1 and MAP2K4. May phosphorylate the MAPK8/JNK1 kinase. Activates CHUK and IKBKB, the central protein kinases of the NF-kappa-B pathway. Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily. Note: This description may include information from UniProtKB.
Protein type: EC; Kinase, protein; Ligase; Protein kinase, STE; Protein kinase, Ser/Thr (non-receptor); STE group; STE11 family; Ubiquitin conjugating system; Ubiquitin ligase
Chromosomal Location of Human Ortholog: 2q14
Cellular Component:  cytoplasm; filamentous actin; membrane
Molecular Function:  ATP binding; cytoskeletal protein binding; JUN kinase binding; JUN kinase kinase kinase activity; MAP kinase kinase kinase activity; mitogen-activated protein kinase binding; mitogen-activated protein kinase kinase binding; protein binding; protein kinase activity; protein kinase binding; protein serine/threonine kinase activity; sphingolipid binding; ubiquitin-protein transferase activity; zinc ion binding
Biological Process:  activation of JNKK activity; activation of JUN kinase activity; activation of MAPKK activity; activation of protein kinase activity; apoptotic mitochondrial changes; camera-type eye development; cellular response to mechanical stimulus; epithelial cell morphogenesis; eyelid development in camera-type eye; JNK cascade; MAPK cascade; morphogenesis of an epithelial sheet; negative regulation of actin filament bundle assembly; peptidyl-serine phosphorylation; positive regulation of actin filament polymerization; positive regulation of apoptotic process; positive regulation of JUN kinase activity; positive regulation of MAP kinase activity; positive regulation of transcription by RNA polymerase II; positive regulation of viral transcription; protein autophosphorylation; protein complex oligomerization; protein phosphorylation; protein polyubiquitination; regulation of cell migration; response to osmotic stress; signal transduction by protein phosphorylation; stress-activated protein kinase signaling cascade; transforming growth factor beta receptor signaling pathway; ubiquitin-dependent protein catabolic process; wound healing
Reference #:  Q62925 (UniProtKB)
Alt. Names/Synonyms: M3K1; Map3k1; MAPK/ERK kinase kinase 1; MEK kinase 1; Mekk; MEKK 1; Mekk1; mitogen activated protein kinase kinase kinase 1; Mitogen-activated protein kinase kinase kinase 1
Gene Symbols: Map3k1
Molecular weight: 161,315 Da
Basal Isoelectric point: 8.03  Predict pI for various phosphorylation states
CST Pathways:  Actin Dynamics  |  B Cell Receptor Signaling  |  ErbB/HER Signaling  |  Growth And Differentiation Control by MAPKs  |  Regulation of P38 MAPKs  |  SAPK/JNK Signaling Cascades  |  T Cell Receptor Signaling  |  TGF-ß Signaling  |  Toll-Like Receptor Signaling
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Protein Structure Not Found.

Cross-references to other databases:  STRING  |  Reactome  |  BioGPS  |  Pfam  |  ENZYME  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene