CACNG3 Regulates the trafficking to the somatodendritic compartment and gating properties of AMPA-selective glutamate receptors (AMPARs). Promotes their targeting to the cell membrane and synapses and modulates their gating properties by slowing their rates of activation, deactivation and desensitization. Does not show subunit-specific AMPA receptor regulation and regulates all AMPAR subunits. Thought to stabilize the calcium channel in an inactivated (closed) state. Belongs to the PMP-22/EMP/MP20 family. CACNG subfamily. Note: This description may include information from UniProtKB.
Protein type: Channel, calcium; Membrane protein, integral; Membrane protein, multi-pass
Chromosomal Location of human Ortholog: 16p12.1
Cellular Component:  AMPA glutamate receptor complex; dendrite; endocytic vesicle membrane; excitatory synapse; glutamatergic synapse; plasma membrane; postsynaptic density membrane; Schaffer collateral - CA1 synapse; somatodendritic compartment; voltage-gated calcium channel complex
Molecular Function:  channel regulator activity; ionotropic glutamate receptor binding; PDZ domain binding; voltage-gated calcium channel activity
Biological Process:  calcium ion transmembrane transport; calcium ion transport; neurotransmitter receptor internalization; neurotransmitter receptor localization to postsynaptic specialization membrane; neurotransmitter receptor transport, postsynaptic endosome to lysosome; positive regulation of AMPA receptor activity; positive regulation of synaptic transmission, glutamatergic; postsynaptic neurotransmitter receptor diffusion trapping; protein localization; protein targeting; regulation of AMPA receptor activity; transmission of nerve impulse
Reference #:  O60359 (UniProtKB)
Alt. Names/Synonyms: Cacng2; CACNG3; calcium channel, voltage-dependent, gamma subunit 3; calcium voltage-gated channel auxiliary subunit gamma 3; CCG3; Neuronal voltage-gated calcium channel gamma-3 subunit; TARP gamma-3; Transmembrane AMPAR regulatory protein gamma-3; Voltage-dependent calcium channel gamma-3 subunit; voltage-gated calcium channel gamma subunit
Gene Symbols: CACNG3
Molecular weight: 35,549 Da
Basal Isoelectric point: 9.53  Predict pI for various phosphorylation states
Select Structure to View Below


Protein Structure Not Found.

Cross-references to other databases:  AlphaFold  |  STRING  |  cBioPortal  |  Wikipedia  |  Reactome  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  InnateDB