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CDS2
Provides CDP-diacylglycerol, an important precursor for the synthesis of phosphatidylinositol, phosphatidylglycerol, and cardiolipin. Belongs to the CDS family. Widely expressed. Expressed in heart, brain and retina, and to a lesser extent in placenta, lung, liver, skeletal muscle, kidney and pancreas. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
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| Protein type: EC 2.7.7.41; Endoplasmic reticulum; Lipid Metabolism - glycerophospholipid; Membrane protein, integral; Membrane protein, multi-pass; Mitochondrial; Transferase |
| Chromosomal Location of human Ortholog: 20p12.3 |
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Cellular Component:
endoplasmic reticulum; endoplasmic reticulum membrane; membrane; mitochondrial inner membrane
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Molecular Function:
phosphatidate cytidylyltransferase activity; protein binding
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Biological Process:
CDP-diacylglycerol biosynthetic process; lipid droplet formation; phosphatidylglycerol biosynthetic process
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Reference #:
O95674
(UniProtKB)
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Alt. Names/Synonyms: CDP-DAG synthase 2; CDP-DG synthase 2; CDP-DG synthetase 2; CDP-diacylglycerol synthase (phosphatidate cytidylyltransferase) 2; CDP-diacylglycerol synthase 2; CDP-diglyceride diphosphorylase 2; CDP-diglyceride pyrophosphorylase 2; CDP-diglyceride synthase 2; CDP-diglyceride synthetase 2; CDS 2; CDS2; CTP:phosphatidate cytidylyltransferase 2; FLJ38111; Phosphatidate cytidylyltransferase 2
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Gene Symbols: CDS2
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Molecular weight:
51,418 Da
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Basal Isoelectric point:
6.64
Predict pI for various phosphorylation states
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