CALCOCO1 Functions as a coactivator for aryl hydrocarbon and nuclear receptors (NR). Recruited to promoters through its contact with the N-terminal basic helix-loop-helix-Per-Arnt-Sim (PAS) domain of transcription factors or coactivators, such as NCOA2. During ER-activation acts synergistically in combination with other NCOA2-binding proteins, such as EP300, CREBBP and CARM1. Involved in the transcriptional activation of target genes in the Wnt/CTNNB1 pathway. Functions as a secondary coactivator in LEF1-mediated transcriptional activation via its interaction with CTNNB1. Coactivator function for nuclear receptors and LEF1/CTNNB1 involves differential utilization of two different activation regions. In association with CCAR1 enhances GATA1- and MED1-mediated transcriptional activation from the gamma-globin promoter during erythroid differentiation of K562 erythroleukemia cells. Seems to enhance inorganic pyrphosphatase thus activating phosphogluomutase (PMG). Probably functions as component of the calphoglin complex, which is involved in linking cellular metabolism (phosphate and glucose metabolism) with other core functions including protein synthesis and degradation, calcium signaling and cell growth. Belongs to the CALCOCO family. 4 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Nuclear receptor co-regulator
Chromosomal Location of human Ortholog: 12q13.13
Cellular Component:  cytosol; intracellular membrane-bounded organelle; nuclear chromatin; nucleus
Molecular Function:  armadillo repeat domain binding; beta-catenin binding; chromatin binding; nuclear receptor transcription coactivator activity; protein binding; protein C-terminus binding; RNA polymerase II distal enhancer sequence-specific DNA binding; sequence-specific DNA binding; transcription coactivator activity; transcription coregulator activity; transcription regulatory region DNA binding
Biological Process:  intracellular steroid hormone receptor signaling pathway; positive regulation of gene expression; positive regulation of transcription by RNA polymerase II; positive regulation of transcription, DNA-templated; signal transduction; Wnt signaling pathway
Reference #:  Q9P1Z2 (UniProtKB)
Alt. Names/Synonyms: CACO1; calcium binding and coiled-coil domain 1; Calcium-binding and coiled-coil domain-containing protein 1; CALCOCO1; Calphoglin; Cocoa; Coiled-coil coactivator protein; coiled-coil leucine zipper coactivator 1; inorganic pyrophosphatase activator; KIAA1536; PP13275; Sarcoma antigen NY-SAR-3
Gene Symbols: CALCOCO1
Molecular weight: 77,336 Da
Basal Isoelectric point: 4.77  Predict pI for various phosphorylation states
Select Structure to View Below


Protein Structure Not Found.

Cross-references to other databases:  AlphaFold  |  STRING  |  cBioPortal  |  Wikipedia  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  NURSA  |  Ensembl Protein