Akt3 one of three AKT kinases of the AGC family that plays a critical role in controlling the balance between survival and apoptosis. AKT3 is the least studied AKT isoform. It plays an important role in brain development and is crucial for the viability of malignant glioma cells. AKT3 isoform may also be the key molecule in up-regulation and down-regulation of MMP13 via IL13. Required for the coordination of mitochondrial biogenesis with growth factor-induced increases in cellular energy demands. Down-regulation by RNA interference reduces the expression of the phosphorylated form of BAD, resulting in the induction of caspase-dependent apoptosis. Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. RAC subfamily. In adult tissues, it is highly expressed in brain, lung and kidney, but weakly in heart, testis and liver. In fetal tissues, it is highly expressed in heart, liver and brain and not at all in kidney. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: AGC group; AKT family; EC; Kinase, protein; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor)
Chromosomal Location of rat Ortholog: 13q25
Cellular Component:  cytosol; membrane; nucleoplasm
Molecular Function:  ATP binding; protein kinase C binding; protein serine/threonine kinase activity
Biological Process:  brain morphogenesis; cellular response to insulin stimulus; homeostasis of number of cells within a tissue; intracellular signal transduction; mitochondrial genome maintenance; negative regulation of cellular senescence; peptidyl-serine phosphorylation; positive regulation of angiogenesis; positive regulation of artery morphogenesis; positive regulation of blood vessel endothelial cell migration; positive regulation of cell migration involved in sprouting angiogenesis; positive regulation of cell size; positive regulation of endothelial cell proliferation; positive regulation of sodium ion transport; positive regulation of TOR signaling; positive regulation of vascular endothelial cell proliferation; protein phosphorylation; signal transduction
Reference #:  Q63484 (UniProtKB)
Alt. Names/Synonyms: Akt3; AKT3 kinase; PKB gamma; Pkbg; Protein kinase Akt-3; Protein kinase B gamma; protein kinase B, gamma; RAC-gamma serine/threonine-protein kinase; RAC-PK-gamma; thymoma viral proto-oncogene 3; v-akt murine thymoma viral oncogene homolog 3 (protein kinase B, gamma)
Gene Symbols: Akt3
Molecular weight: 55,796 Da
Basal Isoelectric point: 5.57  Predict pI for various phosphorylation states
CST Pathways:  Adherens Junction Dynamics  |  Alzheimer's Disease  |  AMPK Signaling  |  Angiogenesis  |  Apoptosis Regulation  |  B Cell Receptor Signaling  |  ErbB/HER Signaling  |  ESC Pluripotency and Differentiation  |  G1/S Checkpoint  |  IL6 Signaling  |  Inhibition of Apoptosis  |  Microtubule Dynamics  |  Mitochondrial Control of Apoptosis  |  mTOR Signaling  |  NF-kB Signaling  |  PI3K/Akt Signaling  |  Protein Kinase C Signaling  |  T Cell Receptor Signaling  |  TGF-ß Signaling  |  Translation: eIF4E and p70S6K  |  Warburg Effect
Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology® Total Proteins
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Cross-references to other databases:  AlphaFold  |  STRING  |  Reactome  |  BioGPS  |  Pfam  |  ENZYME  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  Ensembl Protein