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Akt2
one of three AKT kinases of the AGC family which regulate many processes including metabolism, proliferation, cell survival, growth and angiogenesis. AKT2 plays critical roles in the regulation of glucose uptake and the development or maintenance of proper adipose tissue and islet mass for which other Akt paralogs are unable to fully compensate. Specifically involved in skeletal muscle differentiation. Amplified and overexpressed in human ovarian carcinoma cell lines and amplified in some primary ovarian and pancreatic tumors. Antisense blocks invasiveness in xenografts. Expressed in several insulin-responsive tissues, and one case of Type II diabetes has been associated with a likely LOF point mutation. Mouse mutants have defects in insulin response. Two alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
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| Protein type: AGC group; AKT family; EC 2.7.11.1; Kinase, protein; Oncoprotein; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor) |
| Chromosomal Location of rat Ortholog: 1q21 |
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Cellular Component:
cell cortex; cytosol; early endosome; insulin-responsive compartment; intracellular membrane-bounded organelle; nucleoplasm; nucleus; plasma membrane; protein-containing complex; ruffle membrane; sarcoplasmic reticulum; vesicle
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Molecular Function:
ATP binding; metal ion binding; molecular function activator activity; protein binding; protein kinase activity; protein kinase C binding; protein serine kinase activity; protein serine/threonine kinase activity
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Biological Process:
activation of GTPase activity; carbohydrate transport; cellular response to high light intensity; cellular response to hormone stimulus; cellular response to insulin stimulus; cellular response to organic cyclic compound; glucose metabolic process; glycogen biosynthetic process; insulin receptor signaling pathway; intracellular protein transmembrane transport; intracellular signal transduction; negative regulation of apoptotic process; negative regulation of cysteine-type endopeptidase activity involved in apoptotic process; negative regulation of long-chain fatty acid import across plasma membrane; negative regulation of RNA splicing; peptidyl-serine phosphorylation; peripheral nervous system myelin maintenance; positive regulation of adipose tissue development; positive regulation of cell migration; positive regulation of cell motility; positive regulation of cell population proliferation; positive regulation of fatty acid beta-oxidation; positive regulation of gene expression; positive regulation of glucose import; positive regulation of glucose metabolic process; positive regulation of glycogen biosynthetic process; positive regulation of mitochondrial membrane potential; positive regulation of nitric oxide biosynthetic process; positive regulation of peptidyl-serine phosphorylation; positive regulation of positive chemotaxis; positive regulation of protein phosphorylation; positive regulation of protein targeting to membrane; positive regulation of signal transduction; positive regulation of sodium ion transport; positive regulation of transcription by RNA polymerase II; positive regulation of vesicle fusion; protein kinase B signaling; protein localization to nucleus; protein localization to plasma membrane; protein phosphorylation; regulation of translation; response to hypoxia; response to insulin; response to muscle activity; response to nutrient levels; retinal rod cell apoptotic process
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Reference #:
P47197
(UniProtKB)
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Alt. Names/Synonyms: Akt2; murine thymoma viral (v-akt) oncogene homolog 2; PKB beta; Protein kinase Akt-2; Protein kinase B beta; protein kinase B, beta; RAC protein kinase beta RAC-PK beta; RAC-beta serine/threonine-protein kinase; RAC-PK-beta; thymoma viral proto-oncogene 2; v-akt murine thymoma viral oncogene homolog 2
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Gene Symbols: Akt2
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Molecular weight:
55,543 Da
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Basal Isoelectric point:
5.98
Predict pI for various phosphorylation states
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CST Pathways:
Adherens Junction Dynamics
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Alzheimer's Disease
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AMPK Signaling
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Angiogenesis
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Apoptosis Regulation
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B Cell Receptor Signaling
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ErbB/HER Signaling
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ESC Pluripotency and Differentiation
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G1/S Checkpoint
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IL6 Signaling
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Inhibition of Apoptosis
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Insulin Receptor Signaling
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Microtubule Dynamics
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Mitochondrial Control of Apoptosis
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mTOR Signaling
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NF-kB Signaling
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PI3K/Akt Signaling
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Protein Kinase C Signaling
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T Cell Receptor Signaling
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TGF-ß Signaling
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Translation: eIF4E and p70S6K
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Warburg Effect
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Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology®
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