|
IMPA1
Responsible for the provision of inositol required for synthesis of phosphatidylinositol and polyphosphoinositides and has been implicated as the pharmacological target for lithium action in brain. Has broad substrate specificity and can use myo-inositol monophosphates, myo-inositol 1,3-diphosphate, myo-inositol 1,4-diphosphate, scyllo-inositol-phosphate, D-galactose 1-phosphate, glucose-1-phosphate, glucose-6-phosphate, fructose-1-phosphate, beta-glycerophosphate, and 2'-AMP as substrates. Belongs to the inositol monophosphatase superfamily. 3 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
|
| Protein type: Carbohydrate Metabolism - inositol phosphate; EC 3.1.3.25; EC 3.1.3.94; Motility/polarity/chemotaxis; Phosphatase (non-protein) |
| Chromosomal Location of human Ortholog: 8q21.13 |
|
Cellular Component:
cytoplasm; cytosol
|
|
Molecular Function:
identical protein binding; inositol monophosphate 1-phosphatase activity; inositol monophosphate 3-phosphatase activity; inositol monophosphate 4-phosphatase activity; inositol monophosphate phosphatase activity; lithium ion binding; magnesium ion binding; manganese ion binding; protein binding; protein homodimerization activity
|
|
Biological Process:
inositol biosynthetic process; inositol metabolic process; phosphate-containing compound metabolic process; phosphatidylinositol biosynthetic process; phosphatidylinositol phosphate biosynthetic process; signal transduction
|
|
Disease: Mental Retardation, Autosomal Recessive 59
|
|
Reference #:
P29218
(UniProtKB)
|
|
Alt. Names/Synonyms: D-galactose 1-phosphate phosphatase; IMP; IMP 1; IMPA; IMPA1; IMPase 1; Inositol monophosphatase 1; inositol(myo)-1(or 4)-monophosphatase 1; Inositol-1(or 4)-monophosphatase 1; Lithium-sensitive myo-inositol monophosphatase A1; MRT59; myo-inositol monophosphatase 1; testicular tissue protein Li 94
|
|
Gene Symbols: IMPA1
|
|
Molecular weight:
30,189 Da
|
|
Basal Isoelectric point:
5.16
Predict pI for various phosphorylation states
|
