PKACB Mediates cAMP-dependent signaling triggered by receptor binding to GPCRs. PKA activation regulates diverse cellular processes such as cell proliferation, the cell cycle, differentiation and regulation of microtubule dynamics, chromatin condensation and decondensation, nuclear envelope disassembly and reassembly, as well as regulation of intracellular transport mechanisms and ion flux. Regulates the abundance of compartmentalized pools of its regulatory subunits through phosphorylation of PJA2 which binds and ubiquitinates these subunits, leading to their subsequent proteolysis. Phosphorylates GPKOW which regulates its ability to bind RNA. Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. cAMP subfamily. Isoform 1 is most abundant in the brain, with low level expression in kidney. Isoform 2 is predominantly expressed in thymus, spleen and kidney. Isoform 3 and isoform 4 are only expressed in the brain. 10 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: AGC group; EC; Kinase, protein; PKA family; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor)
Chromosomal Location of Human Ortholog: 3|3 H2
Cellular Component:  cAMP-dependent protein kinase complex; centrosome; ciliary base; cytoplasm; cytosol; intercellular bridge; membrane; nucleus; perinuclear region of cytoplasm; plasma membrane
Molecular Function:  ATP binding; cAMP-dependent protein kinase activity; kinase activity; magnesium ion binding; nucleotide binding; protein kinase A regulatory subunit binding; protein kinase activity; protein serine/threonine kinase activity; transferase activity; ubiquitin protein ligase binding
Biological Process:  adenylate cyclase-modulating G protein-coupled receptor signaling pathway; G protein-coupled receptor signaling pathway; negative regulation of meiotic cell cycle; negative regulation of smoothened signaling pathway involved in dorsal/ventral neural tube patterning; neural tube closure; phosphorylation; protein phosphorylation; regulation of protein processing
Reference #:  P68181 (UniProtKB)
Alt. Names/Synonyms: cAMP-dependent protein kinase C beta; cAMP-dependent protein kinase catalytic subunit beta; KAPCB; OTTMUSP00000017726; PKA C-beta; Pkacb; Prkacb; protein kinase, cAMP dependent, catalytic, beta
Gene Symbols: Prkacb
Molecular weight: 40,708 Da
Basal Isoelectric point: 8.65  Predict pI for various phosphorylation states
CST Pathways:  Actin Dynamics  |  AMPK Signaling  |  GPCR Signaling to MAPKs  |  Growth And Differentiation Control by MAPKs  |  Hedgehog Signaling  |  Inhibition of Apoptosis  |  Insulin Receptor Signaling  |  Microtubule Dynamics  |  Mitochondrial Control of Apoptosis  |  NF-kB Signaling  |  Parkinson's Disease
Select Structure to View Below


Protein Structure Not Found.

Cross-references to other databases:  STRING  |  Reactome  |  BioGPS  |  KinBase  |  Pfam  |  ENZYME  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene