IL20RB
The IL20RA/IL20RB dimer is a receptor for IL19, IL20 and IL24. The IL22RA1/IL20RB dimer is a receptor for IL20 and IL24. Belongs to the type II cytokine receptor family. Widely expressed with highest levels in skin and testis. Highly expressed in psoriatic skin. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
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Protein type: Membrane protein, integral |
Chromosomal Location of human Ortholog: 3q22.3 |
Cellular Component:
plasma membrane
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Molecular Function:
cytokine receptor activity; interleukin-20 binding; protein binding
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Biological Process:
cytokine-mediated signaling pathway; homeostasis of number of cells within a tissue; immune response-inhibiting signal transduction; inflammatory response to antigenic stimulus; negative regulation of interleukin-2 production; negative regulation of T cell proliferation; negative regulation of type II interferon production; negative regulation of type IV hypersensitivity; positive regulation of interleukin-10 production; positive regulation of interleukin-4 production; T cell homeostasis; T cell proliferation
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Reference #:
Q6UXL0
(UniProtKB)
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Alt. Names/Synonyms: DIRS1; fibronectin type III domain containing 6; FNDC6; I20RB; IL-20 receptor subunit beta; IL-20R-beta; IL-20R2; IL-20RB; IL20RB; interleukin 20 receptor beta; interleukin 20 receptor beta subunit; interleukin 20 receptor subunit beta; interleukin-20 receptor II; Interleukin-20 receptor subunit beta; MGC34923
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Gene Symbols: IL20RB
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Molecular weight:
35,076 Da
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Basal Isoelectric point:
4.98
Predict pI for various phosphorylation states
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