IDS Required for the lysosomal degradation of heparan sulfate and dermatan sulfate. Belongs to the sulfatase family. Liver, kidney, lung, and placenta. 3 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: EC 3.1.6.13; Glycan Metabolism - glycosaminoglycan degradation; Hydrolase
Chromosomal Location of Human Ortholog: Xq28
Cellular Component:  lysosomal lumen
Molecular Function:  metal ion binding
Biological Process:  chondroitin sulfate catabolic process; glycosaminoglycan catabolic process
Disease: Mucopolysaccharidosis, Type Ii
Reference #:  P22304 (UniProtKB)
Alt. Names/Synonyms: Alpha-L-iduronate sulfate sulfatase; IDS; Iduronate 2-sulfatase; Iduronate 2-sulfatase 14 kDa chain; Iduronate 2-sulfatase 42 kDa chain; iduronate-2-sulfatase; Idursulfase; MPS2; SIDS
Gene Symbols: IDS
Molecular weight: 61,873 Da
Basal Isoelectric point: 5.21  Predict pI for various phosphorylation states
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IDS

Protein Structure Not Found.


Cross-references to other databases:  STRING  |  cBioPortal  |  Wikipedia  |  Reactome  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  RCSB PDB  |  ENZYME  |  Phospho.ELM  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene