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HSD11B2
Catalyzes the conversion of cortisol to the inactive metabolite cortisone. Modulates intracellular glucocorticoid levels, thus protecting the nonselective mineralocorticoid receptor from occupation by glucocorticoids. Belongs to the short-chain dehydrogenases/reductases (SDR) family. Expressed in kidney, pancreas, prostate, ovary, small intestine and colon. At midgestation, expressed at high levels in placenta and in fetal kidney and, at much lower levels, in fetal lung and testis (PubMed:8530071). Note: This description may include information from UniProtKB.
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| Protein type: EC 1.1.1.-; Lipid Metabolism - C21-steroid hormone; Lipid Metabolism - androgen and estrogen; Oxidoreductase |
| Chromosomal Location of human Ortholog: 16q22.1 |
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Cellular Component:
endoplasmic reticulum membrane; intracellular membrane-bounded organelle; lipid droplet; nucleoplasm
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Molecular Function:
11-beta-hydroxysteroid dehydrogenase (NAD+) activity; NAD binding; oxidoreductase activity; steroid binding; steroid dehydrogenase activity
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Biological Process:
cortisol metabolic process; female pregnancy; glucocorticoid metabolic process; regulation of blood volume by renal aldosterone; response to food; response to glucocorticoid; response to hypoxia; response to insulin; response to xenobiotic stimulus; steroid metabolic process
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Disease: Apparent Mineralocorticoid Excess
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Reference #:
P80365
(UniProtKB)
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Alt. Names/Synonyms: -HSD11 type II; 11-beta-HSD; 11-beta-HSD type II; 11-beta-HSD2; 11-beta-hydroxysteroid dehydrogenase type 2; 11-beta-hydroxysteroid dehydrogenase type II; 11-DH2; 11-HSD type II; AME; AME1; Corticosteroid 11-beta-dehydrogenase isozyme 2; DHI2; HSD11B2; HSD11K; HSD2; hydroxysteroid (11-beta) dehydrogenase 2; hydroxysteroid 11-beta dehydrogenase 2; NAD-dependent 11-beta-hydroxysteroid dehydrogenase; SDR9C3; short chain dehydrogenase/reductase family 9C member 3
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Gene Symbols: HSD11B2
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Molecular weight:
44,127 Da
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Basal Isoelectric point:
9.42
Predict pI for various phosphorylation states
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