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HS3ST6
Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) to catalyze the transfer of a sulfo group to heparan sulfate. The substrate-specific O-sulfation generates an enzyme-modified heparan sulfate which acts as a binding receptor to Herpes Simplex Virus-1 (HSV-1) and permits its entry. Unlike 3-OST-1, does not convert non-anticoagulant heparan sulfate to anticoagulant heparan sulfate. Belongs to the sulfotransferase 1 family. Note: This description may include information from UniProtKB.
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| Protein type: EC 2.8.2.23; Membrane protein, integral; Transferase |
| Chromosomal Location of human Ortholog: 16p13.3 |
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Cellular Component:
Golgi membrane
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Molecular Function:
[heparan sulfate]-glucosamine 3-sulfotransferase 1 activity
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Biological Process:
blastocyst hatching; heparan sulfate proteoglycan biosynthetic process, enzymatic modification
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Disease: Angioedema, Hereditary, 8
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Reference #:
Q96QI5
(UniProtKB)
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Alt. Names/Synonyms: 3-OST-6; h3-OST-6; heparan sulfate (glucosamine) 3-O-sulfotransferase 5; heparan sulfate (glucosamine) 3-O-sulfotransferase 6; Heparan sulfate 3-O-sulfotransferase 6; Heparan sulfate D-glucosaminyl 3-O-sulfotransferase 6; Heparan sulfate glucosamine 3-O-sulfotransferase 6; heparan sulfate-glucosamine 3-sulfotransferase 6; heparan sulphate D-glucosaminyl 3-O-sulfotransferase-3B like; HS3S6; HS3ST5; HS3ST6
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Gene Symbols: HS3ST6
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Molecular weight:
37,186 Da
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Basal Isoelectric point:
10.8
Predict pI for various phosphorylation states
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