Kv1.6 Mediates the voltage-dependent potassium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a potassium-selective channel through which potassium ions may pass in accordance with their electrochemical gradient. Belongs to the potassium channel family. A (Shaker) (TC 1.A.1.2) subfamily. Kv1.6/KCNA6 sub-subfamily. Note: This description may include information from UniProtKB.
Protein type: Membrane protein, integral; Membrane protein, multi-pass
Chromosomal Location of Human Ortholog: 12p13.32
Cellular Component:  axon terminus; integral component of plasma membrane; plasma membrane; potassium channel complex; voltage-gated potassium channel complex
Molecular Function:  delayed rectifier potassium channel activity
Biological Process:  potassium ion transmembrane transport; potassium ion transport; protein homooligomerization; regulation of ion transmembrane transport
Reference #:  P17658 (UniProtKB)
Alt. Names/Synonyms: FLJ25134; HBK2; human brain potassium channel-2; KCNA6; KV1.6; Potassium voltage-gated channel subfamily A member 6; potassium voltage-gated channel, shaker-related subfamily, member 6; Voltage-gated potassium channel HBK2; voltage-gated potassium channel protein Kv1.6; Voltage-gated potassium channel subunit Kv1.6
Gene Symbols: KCNA6
Molecular weight: 58,729 Da
Basal Isoelectric point: 4.9  Predict pI for various phosphorylation states
Select Structure to View Below


Protein Structure Not Found.

Cross-references to other databases:  STRING  |  cBioPortal  |  Wikipedia  |  Reactome  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  InnateDB