Kv1.6 Voltage-gated potassium channel that mediates transmembrane potassium transport in excitable membranes. Forms tetrameric potassium-selective channels through which potassium ions pass in accordance with their electrochemical gradient. The channel alternates between opened and closed conformations in response to the voltage difference across the membrane. Can form functional homotetrameric channels and heterotetrameric channels that contain variable proportions of KCNA1, KCNA2, KCNA4, KCNA6, and possibly other family members as well; channel properties depend on the type of alpha subunits that are part of the channel. Channel properties are modulated by cytoplasmic beta subunits that regulate the subcellular location of the alpha subunits and promote rapid inactivation. Homotetrameric channels display rapid activation and slow inactivation. Belongs to the potassium channel family. A (Shaker) (TC 1.A.1.2) subfamily. Kv1.6/KCNA6 sub-subfamily. Note: This description may include information from UniProtKB.
Protein type: Membrane protein, integral; Membrane protein, multi-pass
Chromosomal Location of human Ortholog: 12p13.32
Cellular Component:  axon terminus; membrane; plasma membrane; potassium channel complex; voltage-gated potassium channel complex
Molecular Function:  delayed rectifier potassium channel activity; protein binding; voltage-gated potassium channel activity
Biological Process:  potassium ion transmembrane transport; potassium ion transport; protein homooligomerization; regulation of ion transmembrane transport
Reference #:  P17658 (UniProtKB)
Alt. Names/Synonyms: FLJ25134; HBK2; human brain potassium channel-2; KCNA6; KV1.6; potassium channel, voltage gated shaker related subfamily A, member 6; Potassium voltage-gated channel subfamily A member 6; potassium voltage-gated channel, shaker-related subfamily, member 6; PPP1R96; protein phosphatase 1, regulatory subunit 96; Voltage-gated potassium channel HBK2; voltage-gated potassium channel protein Kv1.6; Voltage-gated potassium channel subunit Kv1.6
Gene Symbols: KCNA6
Molecular weight: 58,729 Da
Basal Isoelectric point: 4.9  Predict pI for various phosphorylation states
Select Structure to View Below


Protein Structure Not Found.

Cross-references to other databases:  AlphaFold  |  STRING  |  cBioPortal  |  Wikipedia  |  Reactome  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  InnateDB