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STXBP5L
Plays a role in vesicle trafficking and exocytosis inhibition. In pancreatic beta-cells, inhibits insulin secretion probably by interacting with and regulating STX1A and STX4, key t-SNARE proteins involved in the fusion of insulin granules to the plasma membrane. Plays also a role in neurotransmitter release by inhibiting basal acetylcholine release from axon terminals and by preventing synaptic fatigue upon repetitive stimulation. Promotes as well axonal outgrowth. Belongs to the WD repeat L(2)GL family. Detected in kidney, hippocampus and lung carcinoma. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
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| Chromosomal Location of human Ortholog: 3q13.33 |
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Cellular Component:
cytoplasm; plasma membrane; SNARE complex
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Molecular Function:
GTPase activator activity; myosin II binding; protein binding; syntaxin binding
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Biological Process:
exocytosis; protein transport; regulation of exocytosis; regulation of protein secretion
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Reference #:
Q9Y2K9
(UniProtKB)
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Alt. Names/Synonyms: KIAA1006; Lethal(2) giant larvae protein homolog 4; LLGL4; STB5L; STXBP5L; syntaxin binding protein 5 like; syntaxin binding protein 5-like; Syntaxin-binding protein 5-like; Tomosyn-2; tomosyn-like
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Gene Symbols: STXBP5L
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Molecular weight:
131,887 Da
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Basal Isoelectric point:
6.51
Predict pI for various phosphorylation states
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