GMPPB Catalyzes the formation of GDP-mannose, an essential precursor of glycan moieties of glycoproteins and glycolipids. Belongs to the transferase hexapeptide repeat family. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Carbohydrate Metabolism - amino sugar and nucleotide sugar; Carbohydrate Metabolism - fructose and mannose; EC; Motility/polarity/chemotaxis; Transferase
Chromosomal Location of Human Ortholog: 3p21.31
Cellular Component:  cytoplasm
Molecular Function:  GTP binding; mannose-1-phosphate guanylyltransferase activity; protein binding
Biological Process:  GDP-mannose biosynthetic process
Disease: Muscular Dystrophy-dystroglycanopathy (congenital With Brain And Eye Anomalies), Type A, 14; Muscular Dystrophy-dystroglycanopathy (congenital With Mental Retardation), Type B, 14; Muscular Dystrophy-dystroglycanopathy (limb-girdle), Type C, 14
Reference #:  Q9Y5P6 (UniProtKB)
Alt. Names/Synonyms: GDP-mannose pyrophosphorylase B; GMPPB; GTP-mannose-1-phosphate guanylyltransferase beta; KIAA1851; LGMDR19; Mannose-1-phosphate guanyltransferase beta; mannose-1-phosphate guanylyltransferase; MDDGA14; MDDGB14; MDDGC14
Gene Symbols: GMPPB
Molecular weight: 39,834 Da
Basal Isoelectric point: 6.16  Predict pI for various phosphorylation states
Select Structure to View Below


Protein Structure Not Found.

Cross-references to other databases:  STRING  |  cBioPortal  |  Wikipedia  |  Reactome  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  ENZYME  |  Phospho.ELM  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene