FAM38B Component of a mechanosensitive channel required for rapidly adapting mechanically activated (MA) currents. Required for Merkel-cell mechanotransduction. Plays a major role in light-touch mechanosensation. Belongs to the PIEZO (TC 1.A.75) family. 4 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Membrane protein, integral; Membrane protein, multi-pass
Chromosomal Location of Human Ortholog: 18p11.22-p11.21
Cellular Component:  integral component of membrane
Biological Process:  cation transmembrane transport; cation transport; detection of mechanical stimulus involved in sensory perception; response to mechanical stimulus
Reference #:  Q9H5I5 (UniProtKB)
Alt. Names/Synonyms: C18orf30; C18orf58; DA3; DA5; DAIPT; FA38B; FAM38B; FAM38B2; family with sequence similarity 38, member A pseudogene; family with sequence similarity 38, member B; family with sequence similarity 38, member B2; FLJ23144; FLJ23403; FLJ25916; FLJ34907; FLJ37734; FLJ45725; HsT748; HsT771; MWKS; PIEZ2; piezo type mechanosensitive ion channel component 2; piezo-type mechanosensitive ion channel component 1 pseudogene; Piezo-type mechanosensitive ion channel component 2; PIEZO2; PIEZO2 variant 16; Protein FAM38B; protein PIEZO2
Gene Symbols: PIEZO2
Molecular weight: 318,064 Da
Basal Isoelectric point: 5.82  Predict pI for various phosphorylation states
Select Structure to View Below


Protein Structure Not Found.

Cross-references to other databases:  STRING  |  cBioPortal  |  Wikipedia  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  Phospho.ELM  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  InnateDB