HCN1 Hyperpolarization-activated ion channel exhibiting weak selectivity for potassium over sodium ions. Contributes to the native pacemaker currents in heart (If) and in neurons (Ih). May mediate responses to sour stimuli. Belongs to the potassium channel HCN family. Detected in brain, in particular in amygdala and hippocampus, while expression in caudate nucleus, corpus callosum, substantia nigra, subthalamic nucleus and thalamus is very low or not detectable. Detected at very low levels in muscle and pancreas. Note: This description may include information from UniProtKB.
Protein type: Membrane protein, integral; Membrane protein, multi-pass
Chromosomal Location of human Ortholog: 5p12
Cellular Component:  axon; dendrite; HCN channel complex; integral component of plasma membrane; plasma membrane
Molecular Function:  cAMP binding; identical protein binding; intracellular cAMP-activated cation channel activity; potassium channel activity; protein binding; voltage-gated cation channel activity; voltage-gated potassium channel activity; voltage-gated sodium channel activity
Biological Process:  apical protein localization; cellular response to cAMP; potassium ion transmembrane transport; protein homotetramerization; regulation of ion transmembrane transport; regulation of membrane potential; retinal cone cell development; sodium ion transmembrane transport
Disease: Epileptic Encephalopathy, Early Infantile, 24; Generalized Epilepsy With Febrile Seizures Plus, Type 10
Reference #:  O60741 (UniProtKB)
Alt. Names/Synonyms: BCNG-1; BCNG1; brain cyclic nucleotide gated channel 1; Brain cyclic nucleotide-gated channel 1; EIEE24; GEFSP10; HAC-2; HCN1; hyperpolarization activated cyclic nucleotide gated potassium channel 1; hyperpolarization activated cyclic nucleotide-gated potassium channel 1; Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1
Gene Symbols: HCN1
Molecular weight: 98,796 Da
Basal Isoelectric point: 8.63  Predict pI for various phosphorylation states
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Protein Structure Not Found.

Cross-references to other databases:  AlphaFold  |  STRING  |  cBioPortal  |  Wikipedia  |  Reactome  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  RCSB PDB  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  InnateDB