P70S6KB Phosphorylates specifically ribosomal protein S6. Seems to act downstream of mTOR signaling in response to growth factors and nutrients to promote cell proliferation, cell growth and cell cycle progression in an alternative pathway regulated by MEAK7. Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.

Protein type: AGC group; EC 2.7.11.1; Kinase, protein; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor); RSK family; RSKp70 subfamily; Translation

Chromosomal Location of mouse Ortholog: 19|19 A

Cellular Component: cytoplasm; nucleoplasm; nucleus

Molecular Function: ATP binding; kinase activity; nucleotide binding; peptide binding; protein kinase activity; protein serine/threonine kinase activity; ribosomal protein S6 kinase activity; transferase activity

Biological Process: peptidyl-serine phosphorylation; phosphorylation; positive regulation of translational initiation; protein kinase B signaling; protein phosphorylation; TOR signaling

Reference #: Q9Z1M4 (UniProtKB)

Alt. Names/Synonyms: 70 kDa ribosomal protein S6 kinase 2; 70kDa; KS6B2; p70 ribosomal S6 kinase beta; p70 S6 kinase beta; p70 S6K-beta; p70 S6KB; P70S6KB; Ribosomal protein S6 kinase beta-2; ribosomal protein S6 kinase, 70kD, polypeptide 2; ribosomal protein S6 kinase, polypeptide 2; Rps6kb2; S6 kinase 2; S6K; S6K-beta-2; S6K2

Gene Symbols: Rps6kb2

Molecular weight: 53,538 Da

Basal Isoelectric point: 6.72 Predict pI for various phosphorylation states

Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology^®

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P70S6KB