ERCC8 Substrate-recognition component of the CSA complex, a DCX (DDB1-CUL4-X-box) E3 ubiquitin-protein ligase complex, involved in transcription-coupled nucleotide excision repair. The CSA complex (DCX(ERCC8) complex) promotes the ubiquitination and subsequent proteasomal degradation of ERCC6 in a UV-dependent manner; ERCC6 degradation is essential for the recovery of RNA synthesis after transcription-coupled repair. It is required for the recruitment of XAB2, HMGN1 and TCEA1/TFIIS to a transcription-coupled repair complex which removes RNA polymerase II-blocking lesions from the transcribed strand of active genes. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: DNA repair, damage; Helicase; Ubiquitin conjugating system
Chromosomal Location of Human Ortholog: 13|13 D2.1
Cellular Component:  Cul4-RING E3 ubiquitin ligase complex; Cul4A-RING E3 ubiquitin ligase complex; cytoplasm; nuclear matrix; nucleotide-excision repair complex; nucleus; perikaryon; protein-containing complex
Molecular Function:  protein-containing complex binding
Biological Process:  cellular response to DNA damage stimulus; DNA repair; nucleotide-excision repair; positive regulation of DNA repair; proteasome-mediated ubiquitin-dependent protein catabolic process; protein autoubiquitination; protein polyubiquitination; response to oxidative stress; response to UV; response to X-ray; transcription-coupled nucleotide-excision repair
Reference #:  Q8CFD5 (UniProtKB)
Alt. Names/Synonyms: 2410022P04Rik; 2810431L23Rik; 4631412O06Rik; B130065P18Rik; Ckn1; Cockayne syndrome 1 homolog; Cockayne syndrome WD repeat protein CSA homolog; Csa; DNA excision repair protein ERCC-8; Ercc8; excision repaiross-complementing rodent repair deficiency, complementation group 8
Gene Symbols: Ercc8
Molecular weight: 43,689 Da
Basal Isoelectric point: 6.18  Predict pI for various phosphorylation states
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ERCC8

Protein Structure Not Found.


Cross-references to other databases:  STRING  |  Reactome  |  BioGPS  |  Pfam  |  Phospho.ELM  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene