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DUSP13B
Dual specificity phosphatase that dephosphorylates MAPK8/JNK and MAPK14/p38, but not MAPK1/ERK2, in vitro. Exhibits intrinsic phosphatase activity towards both phospho-seryl/threonyl and -tyrosyl residues, with similar specific activities in vitro. Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily. Most abundantly expressed in the testis. Also found in the skeletal muscle. Testis-specific (at protein level). 7 human isoforms generated by alternative promoter usage or alternative splicing have been reported. Note: This description may include information from UniProtKB.
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| Protein type: Cell cycle regulation; EC 3.1.3.16; EC 3.1.3.48; Motility/polarity/chemotaxis; Protein phosphatase, dual-specificity |
| Chromosomal Location of human Ortholog: 10q22.2 |
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Cellular Component:
cytoplasm
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Molecular Function:
MAP kinase phosphatase activity; myosin phosphatase activity; phosphatase activity; protein binding; protein tyrosine phosphatase activity; protein tyrosine/serine/threonine phosphatase activity
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Biological Process:
dephosphorylation; meiotic cell cycle; negative regulation of MAPK cascade; protein dephosphorylation; spermatogenesis
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Reference #:
Q9UII6
(UniProtKB)
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Alt. Names/Synonyms: BEDP; branching-enzyme interacting DSP; branching-enzyme interacting dual-specificity protein phosphatase; DS13B; dual specificity phosphatase 13; Dual specificity phosphatase SKRP4; Dual specificity protein phosphatase 13; Dual specificity protein phosphatase 13 isoform B; dual specificity protein phosphatase 13 isoform MDSP; Dual specificity protein phosphatase 13B; dual-specificity phosphatase SKRP4; DUS13; DUSP13; DUSP13B; FLJ32450; MDSP; muscle-restricted DSP; SKRP4; Testis- and skeletal-muscle-specific DSP; TMDP
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Gene Symbols: DUSP13B
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Molecular weight:
22,149 Da
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Basal Isoelectric point:
9.27
Predict pI for various phosphorylation states
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