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PRKX
Serine/threonine protein kinase regulated by and mediating cAMP signaling in cells. Acts through phosphorylation of downstream targets that may include CREB, SMAD6 and PKD1 and has multiple functions in cellular differentiation and epithelial morphogenesis. Regulates myeloid cell differentiation through SMAD6 phosphorylation. Involved in nephrogenesis by stimulating renal epithelial cell migration and tubulogenesis. Also involved in angiogenesis through stimulation of endothelial cell proliferation, migration and vascular-like structure formation. Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. cAMP subfamily. Widely expressed (at protein level). Specifically expressed in blood by macrophages and granulocytes according to PubMed:9860982. Note: This description may include information from UniProtKB.
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| Protein type: AGC group; EC 2.7.11.1; Kinase, protein; PKA family; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor) |
| Chromosomal Location of mouse Ortholog: X|X B |
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Cellular Component:
cytoplasm; nucleoplasm; nucleus
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Molecular Function:
ATP binding; cAMP-dependent protein kinase activity; kinase activity; nucleotide binding; protein kinase activity; protein serine/threonine kinase activity; transferase activity
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Biological Process:
angiogenesis; cell adhesion; cell differentiation; endothelial cell proliferation; multicellular organism development; phosphorylation; protein phosphorylation
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Reference #:
Q922R0
(UniProtKB)
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Alt. Names/Synonyms: cAMP-dependent protein kinase catalytic subunit PRKX; OTTMUSP00000019439; PKA-related protein kinase; Pkare; PKX1; Prkx; Protein kinase X; Protein kinase X-linked; protein kinase, X-linked; putative serine/threonine kinase; Serine/threonine-protein kinase PRKX
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Gene Symbols: Prkx
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Molecular weight:
40,467 Da
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Basal Isoelectric point:
8.67
Predict pI for various phosphorylation states
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