PRKX Serine/threonine protein kinase regulated by and mediating cAMP signaling in cells. Acts through phosphorylation of downstream targets that may include CREB, SMAD6 and PKD1 and has multiple functions in cellular differentiation and epithelial morphogenesis. Regulates myeloid cell differentiation through SMAD6 phosphorylation. Involved in nephrogenesis by stimulating renal epithelial cell migration and tubulogenesis. Also involved in angiogenesis through stimulation of endothelial cell proliferation, migration and vascular-like structure formation. A chromosomal aberration involving PRKX is a cause of sex reversal disorder. Translocation t(X;Y)(p22;p11) with PRKY. Chromosomal translocations proximal to PRKY account for about 30% of the cases of sex reversal disorder in XX males and XY females. Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. cAMP subfamily. Note: This description may include information from UniProtKB.
Protein type: AGC group; EC; Kinase, protein; PKA family; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor)
Chromosomal Location of Human Ortholog: X|X B
Cellular Component:  cytoplasm; nucleus
Molecular Function:  ATP binding; cAMP-dependent protein kinase activity; kinase activity; nucleotide binding; protein kinase activity; protein serine/threonine kinase activity; transferase activity
Biological Process:  angiogenesis; cell adhesion; cell differentiation; cell-substrate adhesion; endothelial cell migration; endothelial cell proliferation; epithelial tube morphogenesis; kidney morphogenesis; multicellular organism development; myeloid cell differentiation; peptidyl-serine phosphorylation; phosphorylation; protein autophosphorylation; protein phosphorylation; regulation of cell adhesion; regulation of cell migration; regulation of epithelial cell differentiation involved in kidney development
Reference #:  Q922R0 (UniProtKB)
Alt. Names/Synonyms: cAMP-dependent protein kinase catalytic subunit PRKX; OTTMUSP00000019439; PKA-related protein kinase; Pkare; PKX1; Prkx; protein kinase, X-linked; putative serine/threonine kinase; Serine/threonine-protein kinase PRKX
Gene Symbols: Prkx
Molecular weight: 40,467 Da
Basal Isoelectric point: 8.67  Predict pI for various phosphorylation states
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Protein Structure Not Found.

Cross-references to other databases:  STRING  |  BioGPS  |  KinBase  |  Pfam  |  ENZYME  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene