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DET1
Component of the E3 ubiquitin ligase DCX DET1-COP1 complex, which is required for ubiquitination and subsequent degradation of target proteins. The complex is involved in JUN ubiquitination and degradation. Belongs to the DET1 family. Highly expressed in the ovary, some lymphoid organs and resting leukocytes. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
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| Protein type: Ubiquitin ligase |
| Chromosomal Location of human Ortholog: 15q26.1 |
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Cellular Component:
Cul4-RING E3 ubiquitin ligase complex; Cul4A-RING E3 ubiquitin ligase complex; cullin-RING ubiquitin ligase complex; nucleus
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Molecular Function:
protein binding; protein-containing complex binding; ubiquitin ligase-substrate adaptor activity; ubiquitin protein ligase binding
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Biological Process:
positive regulation of proteasomal ubiquitin-dependent protein catabolic process; protein ubiquitination; protein-containing complex assembly
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Reference #:
Q7L5Y6
(UniProtKB)
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Alt. Names/Synonyms: de-etiolated 1; de-etiolated homolog 1; de-etiolated homolog 1 (Arabidopsis); De-etiolated-1 homolog; DET1; DET1 homolog; DET1 partner of COP1 E3 ubiquitin ligase; DET1, COP1 ubiquitin ligase partner; FLJ10103; MGC126156; MGC126157
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Gene Symbols: DET1
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Molecular weight:
63,848 Da
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Basal Isoelectric point:
7.32
Predict pI for various phosphorylation states
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