DBH
Conversion of dopamine to noradrenaline. Belongs to the copper type II ascorbate-dependent monooxygenase family. Note: This description may include information from UniProtKB.
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Protein type: Amino Acid Metabolism - tyrosine; Apoptosis; Cell cycle regulation; EC 1.14.17.1; Membrane protein, integral; Motility/polarity/chemotaxis; Oxidoreductase |
Chromosomal Location of human Ortholog: 9q34.2 |
Cellular Component:
centriolar satellite; chromaffin granule lumen; chromaffin granule membrane; cytoplasm; endoplasmic reticulum; extracellular region; extracellular space; intracellular membrane-bounded organelle; membrane; secretory granule lumen; secretory granule membrane; synapse; transport vesicle membrane
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Molecular Function:
catalytic activity; copper ion binding; dopamine beta-monooxygenase activity; L-ascorbic acid binding; protein binding
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Biological Process:
behavioral response to ethanol; blood vessel remodeling; chemical synaptic transmission; dopamine catabolic process; fear response; glucose homeostasis; homoiothermy; leukocyte mediated immunity; leukocyte migration; locomotory behavior; maternal behavior; memory; norepinephrine biosynthetic process; octopamine biosynthetic process; positive regulation of cold-induced thermogenesis; positive regulation of vasoconstriction; regulation of extrinsic apoptotic signaling pathway; regulation of vascular associated smooth muscle cell proliferation; regulation of vascular endothelial cell proliferation; response to amphetamine; response to pain; vasoconstriction; visual learning
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Disease: Dopamine Beta-hydroxylase Deficiency, Congenital
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Reference #:
P09172
(UniProtKB)
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Alt. Names/Synonyms: DBH; DBM; Dopamine beta-hydroxylase; dopamine beta-hydroxylase (dopamine beta-monooxygenase); Dopamine beta-monooxygenase; DOPO; ORTHYP1; Soluble dopamine beta-hydroxylase
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Gene Symbols: DBH
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Molecular weight:
69,065 Da
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Basal Isoelectric point:
5.97
Predict pI for various phosphorylation states
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Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology®
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