PKG2 Crucial regulator of intestinal secretion and bone growth. Phosphorylates and activates CFTR on the plasma membrane. Plays a key role in intestinal secretion by regulating cGMP-dependent translocation of CFTR in jejunum. Acts downstream of NMDAR to activate the plasma membrane accumulation of GRIA1/GLUR1 in synapse and increase synaptic plasticity. Phosphorylates GRIA1/GLUR1 at Ser-863. Acts as regulator of gene expression and activator of the extracellular signal-regulated kinases MAPK3/ERK1 and MAPK1/ERK2 in mechanically stimulated osteoblasts. Under fluid shear stress, mediates ERK activation and subsequent induction of FOS, FOSL1/FRA1, FOSL2/FRA2 and FOSB that play a key role in the osteoblast anabolic response to mechanical stimulation. Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. cGMP subfamily. Highly concentrated in brain, lung and intestinal mucosa. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: AGC group; EC; Kinase, protein; PKG family; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor)
Chromosomal Location of mouse Ortholog: 5 E3|5 48.35 cM
Cellular Component:  membrane; nuclear membrane; plasma membrane
Molecular Function:  ATP binding; cGMP binding; cGMP-dependent protein kinase activity; kinase activity; nucleotide binding; protein binding; protein homodimerization activity; protein kinase activity; protein serine/threonine kinase activity; transferase activity
Biological Process:  cellular hypotonic response; circadian regulation of gene expression; circadian rhythm; negative regulation of cell volume; negative regulation of chloride transport; peptidyl-serine autophosphorylation; phosphorylation; protein localization to plasma membrane; protein phosphorylation
Reference #:  Q61410 (UniProtKB)
Alt. Names/Synonyms: AW212535; cGK 2; cGK-; cGK-II; cGK2; cGKII; cGMP-dependent protein kinase 2; cGMP-dependent protein kinase II; KGP2; MGC130517; PKG2; Prk; Prkg2; Prkgr2; protein kinase, cGMP-dependent, type II
Gene Symbols: Prkg2
Molecular weight: 87,085 Da
Basal Isoelectric point: 8.44  Predict pI for various phosphorylation states
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Cross-references to other databases:  AlphaFold  |  STRING  |  Reactome  |  BioGPS  |  KinBase  |  Pfam  |  ENZYME  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene