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PTRH2
The natural substrate for this enzyme may be peptidyl-tRNAs which drop off the ribosome during protein synthesis. Promotes caspase-independent apoptosis by regulating the function of two transcriptional regulators, AES and TLE1. Belongs to the PTH2 family. Note: This description may include information from UniProtKB.
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| Protein type: EC 3.1.1.29; Hydrolase; Mitochondrial |
| Chromosomal Location of human Ortholog: 17q23.1 |
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Cellular Component:
cytosol; mitochondrion
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Molecular Function:
aminoacyl-tRNA hydrolase activity; protein binding
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Biological Process:
apoptotic process; negative regulation of anoikis; negative regulation of gene expression; positive regulation of anoikis
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Disease: Neurologic, Endocrine, And Pancreatic Disease, Multisystem, Infantile-onset
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Reference #:
Q9Y3E5
(UniProtKB)
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Alt. Names/Synonyms: Bcl-2 inhibitor of transcription 1; BIT1; CFAP37; CGI-147; cilia and flagella associated protein 37; FLJ32471; IMNEPD; peptidyl-tRNA hydrolase 2; Peptidyl-tRNA hydrolase 2, mitochondrial; PTH; PTH 2; PTH2; PTRH2
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Gene Symbols: PTRH2
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Molecular weight:
19,194 Da
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Basal Isoelectric point:
8.95
Predict pI for various phosphorylation states
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Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology®
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