PTRH2 The natural substrate for this enzyme may be peptidyl-tRNAs which drop off the ribosome during protein synthesis. Promotes caspase-independent apoptosis by regulating the function of two transcriptional regulators, AES and TLE1. Belongs to the PTH2 family. Note: This description may include information from UniProtKB.
Protein type: EC; Hydrolase; Mitochondrial
Chromosomal Location of human Ortholog: 17q23.1
Cellular Component:  cytosol; mitochondrion
Molecular Function:  aminoacyl-tRNA hydrolase activity; protein binding
Biological Process:  apoptotic process; negative regulation of anoikis; negative regulation of gene expression; positive regulation of anoikis
Disease: Neurologic, Endocrine, And Pancreatic Disease, Multisystem, Infantile-onset
Reference #:  Q9Y3E5 (UniProtKB)
Alt. Names/Synonyms: Bcl-2 inhibitor of transcription 1; BIT1; CFAP37; CGI-147; cilia and flagella associated protein 37; FLJ32471; IMNEPD; peptidyl-tRNA hydrolase 2; Peptidyl-tRNA hydrolase 2, mitochondrial; PTH; PTH 2; PTH2; PTRH2
Gene Symbols: PTRH2
Molecular weight: 19,194 Da
Basal Isoelectric point: 8.95  Predict pI for various phosphorylation states
Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology® Total Proteins
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Protein Structure Not Found.

Cross-references to other databases:  AlphaFold  |  STRING  |  cBioPortal  |  Wikipedia  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  RCSB PDB  |  ENZYME  |  Phospho3D  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene