MRPS15 a mitochondrial ribosomal protein encoded by a nuclear gene that helps in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 28S subunit protein that belongs to the ribosomal protein S15P family. The encoded protein is more than two times the size of its E. coli counterpart, with the 12S rRNA binding sites conserved. Between human and mouse, the encoded protein is the least conserved among small subunit ribosomal proteins. Pseudogenes corresponding to this gene are found on chromosomes 15q and 19q. [provided by RefSeq, Jul 2008]
Protein type: Mitochondrial; Ribosomal; Translation
Chromosomal Location of Human Ortholog: 1p34.3
Cellular Component:  mitochondrial inner membrane; mitochondrial small ribosomal subunit; mitochondrion; nucleolus; nucleus
Molecular Function:  structural constituent of ribosome
Biological Process:  mitochondrial translation; mitochondrial translational elongation; mitochondrial translational termination; translation
Reference #:  P82914 (UniProtKB)
Alt. Names/Synonyms: 28S ribosomal protein S15, mitochondrial; DC37; FLJ11564; mitochondrial ribosomal protein S15; MPR-S15; MRP-S15; MRPS15; RPMS15; RT15; S15mt
Gene Symbols: MRPS15
Molecular weight: 29,842 Da
Basal Isoelectric point: 10.48  Predict pI for various phosphorylation states
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Protein Structure Not Found.

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