HSL In adipose tissue and heart, it primarily hydrolyzes stored triglycerides to free fatty acids, while in steroidogenic tissues, it principally converts cholesteryl esters to free cholesterol for steroid hormone production. Belongs to the 'GDXG' lipolytic enzyme family. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: EC; Lipase
Chromosomal Location of Human Ortholog: 1q21
Cellular Component:  caveola; cytoplasm; cytosol; extracellular space; lipid droplet; mitochondrion; nucleus
Molecular Function:  acylglycerol lipase activity; hormone-sensitive lipase activity; hydrolase activity, acting on ester bonds; lipase activity; protein binding; protein kinase binding; rRNA primary transcript binding; serine hydrolase activity; triglyceride lipase activity
Biological Process:  cholesterol metabolic process; diacylglycerol catabolic process; female pregnancy; lipid catabolic process; long-chain fatty acid catabolic process; response to drug; termination of RNA polymerase I transcription; transcription initiation from RNA polymerase I promoter; triglyceride catabolic process
Reference #:  P15304 (UniProtKB)
Alt. Names/Synonyms: hormone - sensitive lipase testicular isoform; Hormone-sensitive lipase; HSL; lipase E; lipase, hormone sensitive; Lipe; LIPS
Gene Symbols: Lipe
Molecular weight: 116,812 Da
Basal Isoelectric point: 6.32  Predict pI for various phosphorylation states
CST Pathways:  AMPK Signaling  |  Insulin Receptor Signaling
Select Structure to View Below


Protein Structure Not Found.

Cross-references to other databases:  STRING  |  Reactome  |  BioGPS  |  Pfam  |  ENZYME  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene