HSL In adipose tissue and heart, it primarily hydrolyzes stored triglycerides to free fatty acids, while in steroidogenic tissues, it principally converts cholesteryl esters to free cholesterol for steroid hormone production. Belongs to the 'GDXG' lipolytic enzyme family. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: EC; Lipase
Chromosomal Location of Human Ortholog: 19q13.2
Cellular Component:  caveola; cytosol; lipid droplet
Molecular Function:  hormone-sensitive lipase activity; protein binding; protein kinase binding; serine hydrolase activity; triglyceride lipase activity
Biological Process:  cholesterol metabolic process; diacylglycerol catabolic process; lipid catabolic process; long-chain fatty acid catabolic process; protein phosphorylation; triglyceride catabolic process
Disease: Abdominal Obesity-metabolic Syndrome 4
Reference #:  Q05469 (UniProtKB)
Alt. Names/Synonyms: Hormone-sensitive lipase; hormone-sensitive lipase testicular isoform; HSL; LHS; lipase, hormone-sensitive; LIPE; LIPS
Gene Symbols: LIPE
Molecular weight: 116,598 Da
Basal Isoelectric point: 6.25  Predict pI for various phosphorylation states
CST Pathways:  AMPK Signaling  |  Insulin Receptor Signaling
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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Protein Structure Not Found.

Cross-references to other databases:  STRING  |  cBioPortal  |  Wikipedia  |  Reactome  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  ENZYME  |  Phospho.ELM  |  NetworKIN  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene