HSL In adipose tissue and heart, it primarily hydrolyzes stored triglycerides to free fatty acids, while in steroidogenic tissues, it principally converts cholesteryl esters to free cholesterol for steroid hormone production. Belongs to the 'GDXG' lipolytic enzyme family. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: EC; Lipase
Chromosomal Location of human Ortholog: 19q13.2
Cellular Component:  caveola; cytosol; lipid droplet; membrane
Molecular Function:  1,2-diacylglycerol acylhydrolase activity; 1,3-diacylglycerol acylhydrolase activity; acylglycerol lipase activity; all-trans-retinyl-palmitate hydrolase, all-trans-retinol forming activity; hormone-sensitive lipase activity; protein binding; retinyl-palmitate esterase activity; sterol esterase activity; triglyceride lipase activity
Biological Process:  cholesterol metabolic process; diacylglycerol catabolic process; ether lipid metabolic process; lipid catabolic process; protein phosphorylation; retinol metabolic process; triglyceride catabolic process
Disease: Abdominal Obesity-metabolic Syndrome 4
Reference #:  Q05469 (UniProtKB)
Alt. Names/Synonyms: AOMS4; FPLD6; Hormone-sensitive lipase; hormone-sensitive lipase testicular isoform; HSL; LHS; lipase E, hormone sensitive type; lipase, hormone-sensitive; LIPE; LIPS; Monoacylglycerol lipase LIPE; REH; Retinyl ester hydrolase
Gene Symbols: LIPE
Molecular weight: 116,598 Da
Basal Isoelectric point: 6.25  Predict pI for various phosphorylation states
CST Pathways:  AMPK Signaling  |  Insulin Receptor Signaling
Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology® Total Proteins
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Protein Structure Not Found.

Cross-references to other databases:  AlphaFold  |  STRING  |  cBioPortal  |  Wikipedia  |  Reactome  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  ENZYME  |  Phospho.ELM  |  NetworKIN  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  Ensembl Protein