HSL In adipose tissue and heart, it primarily hydrolyzes stored triglycerides to free fatty acids, while in steroidogenic tissues, it principally converts cholesteryl esters to free cholesterol for steroid hormone production. Belongs to the 'GDXG' lipolytic enzyme family. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: EC; Lipase
Chromosomal Location of Human Ortholog: 7 A3|7 13.78 cM
Cellular Component:  caveola; cytoplasm; cytosol; extracellular space; lipid droplet; membrane; mitochondrion; nucleus; plasma membrane
Molecular Function:  acylglycerol lipase activity; hormone-sensitive lipase activity; hydrolase activity; hydrolase activity, acting on ester bonds; lipase activity; protein binding; protein kinase binding; rRNA primary transcript binding; serine hydrolase activity; triglyceride lipase activity
Biological Process:  cholesterol metabolic process; diacylglycerol catabolic process; lipid catabolic process; lipid metabolic process; long-chain fatty acid catabolic process; steroid metabolic process; termination of RNA polymerase I transcription; transcription initiation from RNA polymerase I promoter; triglyceride catabolic process
Reference #:  P54310 (UniProtKB)
Alt. Names/Synonyms: 4933403G17Rik; Hormone-sensitive lipase; HSL; lipase E; lipase, hormone sensitive; Lipe; LIPS; Monoacylglycerol lipase LIPE; REH; Retinyl ester hydrolase
Gene Symbols: Lipe
Molecular weight: 83,348 Da
Basal Isoelectric point: 6.49  Predict pI for various phosphorylation states
CST Pathways:  AMPK Signaling  |  Insulin Receptor Signaling
Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology® Total Proteins
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Protein Structure Not Found.

Cross-references to other databases:  STRING  |  Reactome  |  BioGPS  |  Pfam  |  ENZYME  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene  |  Ensembl Protein