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Arp3
Functions as ATP-binding component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. Seems to contact the pointed end of the daughter actin filament. Plays a role in ciliogenesis. Component of the Arp2/3 complex composed of ARP2, ARP3, ARPC1B/p41-ARC, ARPC2/p34-ARC, ARPC3/p21-ARC, ARPC4/p20-ARC and ARPC5/p16-ARC. Interacts with WHDC1. Belongs to the actin family. ARP3 subfamily. Note: This description may include information from UniProtKB.
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| Protein type: Cytoskeletal; Motility/polarity/chemotaxis |
| Chromosomal Location of Human Ortholog: 13q12 |
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Cellular Component:
actin cortical patch; apical ectoplasmic specialization; apical tubulobulbar complex; Arp2/3 protein complex; basal ectoplasmic specialization; brush border; cell leading edge; cell-cell junction; concave side of sperm head; cytoplasm; excitatory synapse; glutamatergic synapse; Golgi membrane; hemidesmosome; lamellipodium; leading edge of lamellipodium; nucleus; perinuclear region of cytoplasm; podosome; podosome core; postsynapse; ruffle; site of double-strand break
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Molecular Function:
actin binding; actin filament binding; ATP binding; ATPase binding; protein binding; structural constituent of cytoskeleton
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Biological Process:
Arp2/3 complex-mediated actin nucleation; astrocyte differentiation; asymmetric cell division; cellular response to epidermal growth factor stimulus; cellular response to interferon-gamma; cellular response to interleukin-1; cellular response to pyrimidine ribonucleotide; cellular response to transforming growth factor beta stimulus; cellular response to trichostatin A; cellular response to triterpenoid; cellular response to tumor necrosis factor; cilium assembly; establishment or maintenance of cell polarity; meiotic cell cycle; meiotic chromosome movement towards spindle pole; meiotic cytokinesis; negative regulation of axon extension; negative regulation of bleb assembly; positive regulation of actin cytoskeleton reorganization; positive regulation of actin filament polymerization; positive regulation of astrocyte differentiation; positive regulation of dendrite morphogenesis; positive regulation of dendritic spine morphogenesis; positive regulation of fibroblast migration; positive regulation of filopodium assembly; positive regulation of lamellipodium assembly; positive regulation of neuron differentiation; positive regulation of protein binding; positive regulation of protein localization to plasma membrane; positive regulation of protein targeting to membrane; positive regulation of synapse assembly; positive regulation of transcription by RNA polymerase II; postsynaptic actin cytoskeleton organization; regulation of myosin II filament organization; response to estradiol; response to heparin; Sertoli cell barrier remodeling; spermatogenesis; spindle localization
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Reference #:
Q4V7C7
(UniProtKB)
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Alt. Names/Synonyms: Actin-like protein 3; Actin-related protein 3; actin-related protein 3 homolog (yest); Actr3; Arp3; ARP3 actin-related protein 3 homolog (yeast); MGC116163
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Gene Symbols: Actr3
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Molecular weight:
47,357 Da
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Basal Isoelectric point:
5.61
Predict pI for various phosphorylation states
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CST Pathways:
Actin Dynamics
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Adherens Junction Dynamics
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