CREB3L4
Transcriptional activator that may play a role in the unfolded protein response. Binds to the UPR element (UPRE) but not to CRE element. Preferentially binds DNA with to the consensus sequence 5'-T[GT]ACGT[GA][GT]-3' and has transcriptional activation activity from UPRE. Binds to NF-kappa-B site and has transcriptional activation activity from NF-kappa-B-containing regulatory elements. Belongs to the bZIP family. ATF subfamily. According to PubMed:11830526, exclusively expressed in the prostate. Expressed in breast and prostate cancer cell lines. Expressed in prostatic luminal epithelial cells (at protein level). Expression is significantly more abundant in prostate cancer than in benign prostatic tissue (prostatic hyperplasia). According to PubMed:12111373, also expressed in brain, pancreas and skeletal muscle, and at lower levels in small intestine, testis, leukocyte and thymus. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
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Protein type: Endoplasmic reticulum; Membrane protein, integral; Transcription factor |
Chromosomal Location of human Ortholog: 1q21.3 |
Cellular Component:
chromatin; endoplasmic reticulum; endoplasmic reticulum membrane; Golgi apparatus; Golgi membrane; mitochondrion; nuclear membrane; nucleoplasm; nucleus
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Molecular Function:
DNA-binding transcription activator activity, RNA polymerase II-specific; DNA-binding transcription factor activity, RNA polymerase II-specific; protein binding; RNA polymerase II cis-regulatory region sequence-specific DNA binding; sequence-specific double-stranded DNA binding
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Biological Process:
positive regulation of transcription by RNA polymerase II; regulation of transcription by RNA polymerase II; response to unfolded protein; spermatogenesis
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Reference #:
Q8TEY5
(UniProtKB)
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Alt. Names/Synonyms: AIBZIP; Androgen-induced basic leucine zipper protein; ATCE1; Attaching to CRE-like 1; cAMP responsive element binding protein 1; cAMP responsive element binding protein 3 like 4; cAMP responsive element binding protein 3-like 4; cAMP-responsive element-binding protein 3-like protein 4; cAMP-responsive element-binding protein 4; CR3L4; CREB-4; CREB3; CREB3L4; CREB4; Cyclic AMP-responsive element-binding protein 3-like protein 4; Cyclic AMP-responsive element-binding protein 4; hJAL; JAL; Processed cyclic AMP-responsive element-binding protein 3-like protein 4; Tisp40; Transcript induced in spermiogenesis protein 40
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Gene Symbols: CREB3L4
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Molecular weight:
43,432 Da
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Basal Isoelectric point:
5.28
Predict pI for various phosphorylation states
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