| PFKFB3 Synthesis and degradation of fructose 2,6-bisphosphate. In the C-terminal section; belongs to the phosphoglycerate mutase family. Ubiquitous. 4 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB. |
| Protein type: Carbohydrate Metabolism - fructose and mannose; EC 2.7.1.105; EC 3.1.3.46; Kinase, other; Motility/polarity/chemotaxis; Phosphatase (non-protein) |
| Chromosomal Location of human Ortholog: 10p15.1 |
| Cellular Component: cytosol; nucleoplasm |
| Molecular Function: 6-phosphofructo-2-kinase activity; ATP binding; fructose-2,6-bisphosphate 2-phosphatase activity; protein binding |
| Biological Process: carbohydrate phosphorylation; fructose 2,6-bisphosphate metabolic process; fructose metabolic process |
| Reference #: Q16875 (UniProtKB) |
| Alt. Names/Synonyms: 6-phosphofructo-2-kinase; 6-phosphofructo-2-kinase/ fructose-2,6-bisphosphatase; 6-phosphofructo-2-kinase/fructose-2, 6-bisphosphatase; 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3; 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3; 6PF-2-K/Fru-2,6-P2ase 3; 6PF-2-K/Fru-2,6-P2ase brain/placenta-type isozyme; F263; FLJ37326; Fructose-2,6-bisphosphatase; fructose-6-phosphate,2-kinase/fructose-2, 6-bisphosphatase; inducible 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase; iPFK-2; IPFK2; PFK/FBPase 3; PFK2; PFKFB3; Renal carcinoma antigen NY-REN-56 |
| Gene Symbols: PFKFB3 |
| Molecular weight: 59,609 Da |
| Basal Isoelectric point: 8.49 Predict pI for various phosphorylation states |
| CST Pathways: AMPK Signaling | Warburg Effect |
Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology®
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PFKFB3 |
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Cross-references to other databases:
AlphaFold
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STRING
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cBioPortal
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Wikipedia
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Reactome
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neXtProt
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Protein Atlas
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BioGPS
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Pfam
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