nAChRB4 After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane. Belongs to the ligand-gated ion channel (TC 1.A.9) family. Acetylcholine receptor (TC 1.A.9.1) subfamily. Beta-4/CHRNB4 sub-subfamily. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Channel, cation; Channel, ligand-gated; Membrane protein, integral; Membrane protein, multi-pass; Receptor, misc.
Chromosomal Location of human Ortholog: 15q25.1
Cellular Component:  acetylcholine-gated channel complex; cholinergic synapse; membrane; neuron projection; plasma membrane; postsynaptic membrane; specific granule membrane; synapse; tertiary granule membrane
Molecular Function:  acetylcholine receptor activity; acetylcholine-gated cation-selective channel activity; excitatory extracellular ligand-gated ion channel activity; ligand-gated ion channel activity; neurotransmitter receptor activity; protein binding; transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential
Biological Process:  behavioral response to nicotine; chemical synaptic transmission; excitatory postsynaptic potential; ion transmembrane transport; ion transport; locomotory behavior; nervous system process; neuronal action potential; positive regulation of transmission of nerve impulse; regulation of membrane potential; regulation of neurotransmitter secretion; regulation of smooth muscle contraction; signal transduction; smooth muscle contraction; synaptic transmission involved in micturition; synaptic transmission, cholinergic
Reference #:  P30926 (UniProtKB)
Alt. Names/Synonyms: acetylcholine receptor, nicotinic, beta 4 (neuronal); ACHB4; cholinergic receptor nicotinic beta 4 subunit; cholinergic receptor, nicotinic, beta 4; cholinergic receptor, nicotinic, beta 4 (neuronal); cholinergic receptor, nicotinic, beta polypeptide 4; CHRNB4; nAChRB4; Neuronal acetylcholine receptor subunit beta-4; neuronal nicotinic receptor beta 4 subunit
Gene Symbols: CHRNB4
Molecular weight: 56,380 Da
Basal Isoelectric point: 8.64  Predict pI for various phosphorylation states
CST Pathways:  Alzheimer's Disease
Select Structure to View Below


Protein Structure Not Found.

Cross-references to other databases:  AlphaFold  |  STRING  |  cBioPortal  |  Wikipedia  |  Reactome  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  RCSB PDB  |  Phospho.ELM  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene