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nAChRB4
After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane. Belongs to the ligand-gated ion channel (TC 1.A.9) family. Acetylcholine receptor (TC 1.A.9.1) subfamily. Beta-4/CHRNB4 sub-subfamily. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
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| Protein type: Channel, cation; Channel, ligand-gated; Membrane protein, integral; Membrane protein, multi-pass; Receptor, misc. |
| Chromosomal Location of human Ortholog: 15q25.1 |
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Cellular Component:
acetylcholine-gated channel complex; cholinergic synapse; membrane; neuron projection; plasma membrane; postsynaptic membrane; specific granule membrane; synapse; tertiary granule membrane
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Molecular Function:
acetylcholine receptor activity; acetylcholine-gated cation-selective channel activity; excitatory extracellular ligand-gated ion channel activity; ligand-gated ion channel activity; neurotransmitter receptor activity; protein binding; transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential
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Biological Process:
behavioral response to nicotine; chemical synaptic transmission; excitatory postsynaptic potential; ion transmembrane transport; ion transport; locomotory behavior; nervous system process; neuronal action potential; positive regulation of transmission of nerve impulse; regulation of membrane potential; regulation of neurotransmitter secretion; regulation of smooth muscle contraction; signal transduction; smooth muscle contraction; synaptic transmission involved in micturition; synaptic transmission, cholinergic
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Reference #:
P30926
(UniProtKB)
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Alt. Names/Synonyms: acetylcholine receptor, nicotinic, beta 4 (neuronal); ACHB4; cholinergic receptor nicotinic beta 4 subunit; cholinergic receptor, nicotinic, beta 4; cholinergic receptor, nicotinic, beta 4 (neuronal); cholinergic receptor, nicotinic, beta polypeptide 4; CHRNB4; nAChRB4; Neuronal acetylcholine receptor subunit beta-4; neuronal nicotinic receptor beta 4 subunit
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Gene Symbols: CHRNB4
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Molecular weight:
56,380 Da
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Basal Isoelectric point:
8.64
Predict pI for various phosphorylation states
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CST Pathways:
Alzheimer's Disease
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