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nAChRB3
After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane. Belongs to the ligand-gated ion channel (TC 1.A.9) family. Acetylcholine receptor (TC 1.A.9.1) subfamily. Beta-3/CHRNB3 sub-subfamily. Note: This description may include information from UniProtKB.
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| Protein type: Channel, cation; Channel, ligand-gated; Membrane protein, integral; Membrane protein, multi-pass |
| Chromosomal Location of mouse Ortholog: 8|8 A2 |
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Cellular Component:
acetylcholine-gated channel complex; dopaminergic synapse; membrane; neuron projection; plasma membrane; postsynaptic membrane; protein-containing complex; synapse
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Molecular Function:
acetylcholine binding; acetylcholine receptor activity; acetylcholine-gated monoatomic cation-selective channel activity; extracellular ligand-gated monoatomic ion channel activity; heterocyclic compound binding; monoatomic ion channel activity; transmembrane signaling receptor activity
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Biological Process:
monoatomic ion transmembrane transport; monoatomic ion transport; nervous system process; presynaptic modulation of chemical synaptic transmission; regulation of membrane potential; response to nicotine; signal transduction; synaptic transmission, cholinergic
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Reference #:
Q8BMN3
(UniProtKB)
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Alt. Names/Synonyms: 5730417K16Rik; ACHB3; Acr; Acrb3; cholinergic receptor, nicotinic, beta polypeptide 3; Chrnb3; nAChRB3; Neuronal acetylcholine receptor subunit beta-3
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Gene Symbols: Chrnb3
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Molecular weight:
53,112 Da
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Basal Isoelectric point:
8.86
Predict pI for various phosphorylation states
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CST Pathways:
Alzheimer's Disease
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