|
CDK2AP2
Plays a role in regulating the self-renewal of embryonic stem cells (ESCs) and in maintaining cell survival during terminal differentiation of ESCs. Regulates microtubule organization of metaphase II oocytes. Inhibits cell cycle G1/S phase transition by repressing CDK2 expression and activation; represses CDK2 activation by inhibiting its interaction with cyclin E and A. Belongs to the CDK2AP family. Ubiquitous. Note: This description may include information from UniProtKB.
|
| Protein type: Cell cycle regulation |
| Chromosomal Location of human Ortholog: 11q13.2 |
|
Cellular Component:
cytoplasm; microtubule; nucleus; NuRD complex
|
|
Molecular Function:
protein binding
|
|
Biological Process:
negative regulation of G1/S transition of mitotic cell cycle; regulation of microtubule cytoskeleton organization; regulation of stem cell division
|
|
Reference #:
O75956
(UniProtKB)
|
|
Alt. Names/Synonyms: CDK2-associated protein 2; CDK2AP2; CDKA2; cyclin dependent kinase 2 associated protein 2; cyclin-dependent kinase 2 associated protein 2; Cyclin-dependent kinase 2-associated protein 2; DOC-1-related protein; DOC-1R; DOC1R; FLJ10636; p14; tumor suppressor deleted in oral cancer related 1; tumor suppressor deleted in oral cancer-related 1
|
|
Gene Symbols: CDK2AP2
|
|
Molecular weight:
13,101 Da
|
|
Basal Isoelectric point:
9.51
Predict pI for various phosphorylation states
|
