LATS1 an AGC kinase of the NDR family of kinases. Localized to the mitotic apparatus and specifically phosphorylated during mitosis. A likely tumor suppressor which plays a critical role in maintenance of ploidy through its actions in both mitotic progression and the G1 tetraploidy checkpoint. Negatively regulates G2/M transition by down-regulating CDC2 kinase activity, causing G2 arrest. Involved in the control of p53 expression. Affects cytokinesis by regulating actin polymerization through negative modulation of LIMK1. Complexes with CDC2 in early mitosis. LATS1-associated CDC2 has no mitotic cyclin partner and no apparent kinase activity. Binds phosphorylated zyxin, locating this protein to the mitotic spindle and suggesting a role for actin regulatory proteins during mitosis. Binds to and colocalizes with LIMK1 at the actomyosin contractile ring during cytokinesis. Knockout mice are susceptible to soft-tissue sarcomas and sensitive to chemical carcinogenesis. Human soft tissue sarcomas have downregulated, mutated, and/or hypermethylated LATS1. Transgenic expression blocks anchorage independent growth in culture and tumor growth in xenografts. Two alternatively spliced isoforms of the human proteinhave been described. Note: This description may include information from UniProtKB.
Protein type: AGC group; EC; Kinase, protein; NDR family; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor); Tumor suppressor
Chromosomal Location of Human Ortholog: 10|10 A1
Cellular Component:  cytoplasm; cytoskeleton; spindle pole
Molecular Function:  ATP binding; estrogen receptor binding; kinase activity; magnesium ion binding; metal ion binding; nucleotide binding; protein kinase activity; protein kinase binding; protein serine/threonine kinase activity; transferase activity
Biological Process:  cell cycle; cell division; cellular protein localization; cytoplasmic sequestering of protein; G1/S transition of mitotic cell cycle; G2/M transition of mitotic cell cycle; hippo signaling; hormone-mediated signaling pathway; inner cell mass cell fate commitment; inner cell mass cellular morphogenesis; intracellular signal transduction; keratinocyte differentiation; mammary gland epithelial cell differentiation; mitotic cell cycle; negative regulation of canonical Wnt signaling pathway; negative regulation of cyclin-dependent protein serine/threonine kinase activity; peptidyl-serine phosphorylation; phosphorylation; positive regulation of apoptotic process; positive regulation of peptidyl-serine phosphorylation; protein phosphorylation; regulation of actin filament polymerization; regulation of intracellular estrogen receptor signaling pathway; regulation of organ growth; regulation of protein complex assembly; regulation of ubiquitin-dependent protein catabolic process; sister chromatid segregation
Reference #:  Q8BYR2 (UniProtKB)
Alt. Names/Synonyms: AW208599; large tumor suppressor; Large tumor suppressor homolog 1; large tumor supressor, homolog 1; Lats1; Serine/threonine-protein kinase LATS1; Warts; WARTS protein kinase
Gene Symbols: Lats1
Molecular weight: 126,258 Da
Basal Isoelectric point: 8.88  Predict pI for various phosphorylation states
CST Pathways:  Hippo Signaling
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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Cross-references to other databases:  STRING  |  Reactome  |  BioGPS  |  KinBase  |  Pfam  |  RCSB PDB  |  ENZYME  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene