LATS1 Negative regulator of YAP1 in the Hippo signaling pathway that plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein STK3/MST2 and STK4/MST1, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Phosphorylation of YAP1 by LATS1 inhibits its translocation into the nucleus to regulate cellular genes important for cell proliferation, cell death, and cell migration. Acts as a tumor suppressor which plays a critical role in maintenance of ploidy through its actions in both mitotic progression and the G1 tetraploidy checkpoint. Negatively regulates G2/M transition by down-regulating CDK1 kinase activity. Involved in the control of p53 expression. Affects cytokinesis by regulating actin polymerization through negative modulation of LIMK1. May also play a role in endocrine function. Plays a role in mammary gland epithelial cells differentiation, both through the Hippo signaling pathway and the intracellular estrogen receptor signaling pathway by promoting the degradation of ESR1. Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. Expressed in all adult tissues examined except for lung and kidney. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: AGC group; EC 2.7.11.1; Kinase, protein; NDR family; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor); Tumor suppressor
Chromosomal Location of Human Ortholog: 6q25.1
Cellular Component:  cytosol; microtubule organizing center; spindle pole
Molecular Function:  ATP binding; estrogen receptor binding; magnesium ion binding; protein binding; protein kinase binding; protein serine/threonine kinase activity
Biological Process:  cell division; cellular protein localization; cytoplasmic sequestering of protein; G2/M transition of mitotic cell cycle; hippo signaling; hormone-mediated signaling pathway; inner cell mass cell fate commitment; inner cell mass cellular morphogenesis; keratinocyte differentiation; mammary gland epithelial cell differentiation; negative regulation of canonical Wnt signaling pathway; negative regulation of cyclin-dependent protein serine/threonine kinase activity; positive regulation of peptidyl-serine phosphorylation; protein phosphorylation; regulation of actin filament polymerization; regulation of intracellular estrogen receptor signaling pathway; regulation of protein complex assembly; regulation of ubiquitin-dependent protein catabolic process; sister chromatid segregation
Reference #:  O95835 (UniProtKB)
Alt. Names/Synonyms: h-warts; Large tumor suppressor homolog 1; LATS (large tumor suppressor, Drosophila) homolog 1; LATS, large tumor suppressor, homolog 1 (Drosophila); LATS1; Serine/threonine-protein kinase LATS1; WARTS; WARTS protein kinase; wts
Gene Symbols: LATS1
Molecular weight: 126,870 Da
Basal Isoelectric point: 8.84  Predict pI for various phosphorylation states
CST Pathways:  Hippo Signaling
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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LATS1

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