LATS2 an AGC kinase of the NDR family of kinases. A tumor suppressor of the LATS family. Plays a critical role in centrosome duplication, maintenance of mitotic fidelity and genomic stability. Inhibits cell growth at the G1/S transition by down-regulating cyclin E/CDK2 kinase activity. Negative regulator of the androgen receptor. Interacts with and is phosphorylated by STK6. Ectopic expression induces apoptosis in lung cancer cell lines. Negatively regulates androgen receptor, and is downregulated in prostate cancer Note: This description may include information from UniProtKB.
Protein type: AGC group; EC; Kinase, protein; NDR family; Nuclear receptor co-regulator; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor); Tumor suppressor
Chromosomal Location of Human Ortholog: 14|14 C3
Cellular Component:  cytoplasm; cytoskeleton; cytosol; microtubule organizing center; nucleus; spindle pole
Molecular Function:  ATP binding; kinase activity; metal ion binding; nucleotide binding; protein kinase activity; protein serine/threonine kinase activity; transferase activity
Biological Process:  cell cycle; cell division; cellular protein localization; G1/S transition of mitotic cell cycle; hippo signaling; hormone-mediated signaling pathway; inner cell mass cell fate commitment; inner cell mass cellular morphogenesis; intracellular signal transduction; keratinocyte differentiation; negative regulation of canonical Wnt signaling pathway; negative regulation of cyclin-dependent protein serine/threonine kinase activity; peptidyl-serine phosphorylation; phosphorylation; positive regulation of apoptotic process; protein phosphorylation; regulation of organ growth
Reference #:  Q7TSJ6 (UniProtKB)
Alt. Names/Synonyms: 4932411G09Rik; AV277261; AW228608; Kinase phosphorylated during mitosis protein; large tumor suppressor 2; Large tumor suppressor homolog 2; Lats2; Serine/threonine-protein kinase kpm; Serine/threonine-protein kinase LATS2
Gene Symbols: Lats2
Molecular weight: 115,472 Da
Basal Isoelectric point: 8.45  Predict pI for various phosphorylation states
CST Pathways:  Hippo Signaling
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Cross-references to other databases:  STRING  |  Reactome  |  BioGPS  |  KinBase  |  Pfam  |  RCSB PDB  |  ENZYME  |  Phospho3D  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene  |  NURSA