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LATS2
Negative regulator of YAP1 in the Hippo signaling pathway that plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein STK3/MST2 and STK4/MST1, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Phosphorylation of YAP1 by LATS2 inhibits its translocation into the nucleus to regulate cellular genes important for cell proliferation, cell death, and cell migration. Acts as a tumor suppressor which plays a critical role in centrosome duplication, maintenance of mitotic fidelity and genomic stability. Negatively regulates G1/S transition by down-regulating cyclin E/CDK2 kinase activity. Negative regulator of the androgen receptor. Phosphorylates SNAI1 in the nucleus leading to its nuclear retention and stabilization, which enhances its epithelial-mesenchymal transition and tumor cell invasion/migration activities. This tumor-promoting activity is independent of its effects upon YAP1 or WWTR1/TAZ. Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. Expressed at high levels in heart and skeletal muscle and at lower levels in all other tissues examined. Note: This description may include information from UniProtKB.
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| Protein type: AGC group; EC 2.7.11.1; Kinase, protein; LATS subfamily; NDR family; Nuclear receptor co-regulator; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor); Tumor suppressor |
| Chromosomal Location of mouse Ortholog: 14|14 C3 |
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Cellular Component:
centriolar satellite; cytoplasm; cytoskeleton; cytosol; nucleus; spindle pole
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Molecular Function:
ATP binding; kinase activity; metal ion binding; nucleotide binding; protein kinase activity; protein serine/threonine kinase activity; transferase activity
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Biological Process:
canonical Wnt signaling pathway; cell cycle; cell division; G1/S transition of mitotic cell cycle; hippo signaling; hormone-mediated signaling pathway; inner cell mass cell fate commitment; inner cell mass cellular morphogenesis; intracellular signal transduction; keratinocyte differentiation; negative regulation of canonical Wnt signaling pathway; negative regulation of cyclin-dependent protein serine/threonine kinase activity; negative regulation of protein localization to nucleus; peptidyl-serine phosphorylation; phosphorylation; positive regulation of apoptotic process; protein localization; protein phosphorylation; regulation of organ growth; regulation of transforming growth factor beta receptor signaling pathway
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Reference #:
Q7TSJ6
(UniProtKB)
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Alt. Names/Synonyms: 4932411G09Rik; AV277261; AW228608; Kinase phosphorylated during mitosis protein; large tumor suppressor 2; Large tumor suppressor homolog 2; Lats2; Serine/threonine-protein kinase kpm; Serine/threonine-protein kinase LATS2
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Gene Symbols: Lats2
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Molecular weight:
115,472 Da
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Basal Isoelectric point:
8.45
Predict pI for various phosphorylation states
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CST Pathways:
Hippo Signaling
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