IKKG a regulatory subunit of the IKK-signalosome complex. Interacts preferentially with IKK-beta but also able to interact with IKK-alpha, IKAP, TAX, RIP and MAP3K14/NIK. Defects are the cause of familial incontinentia pigmenti type II (IP2). Note: This description may include information from UniProtKB.
Protein type: Adaptor/scaffold; Protein kinase, regulatory subunit
Chromosomal Location of Human Ortholog: X|X A7.3
Cellular Component:  cytoplasm; cytosol; IkappaB kinase complex; mitotic spindle; nucleus; spindle pole; ubiquitin ligase complex
Molecular Function:  identical protein binding; K63-linked polyubiquitin modification-dependent protein binding; linear polyubiquitin binding; metal ion binding; peroxisome proliferator activated receptor binding; protein binding; protein domain specific binding; protein heterodimerization activity; protein homodimerization activity; ubiquitin protein ligase binding
Biological Process:  activation of NF-kappaB-inducing kinase activity; anoikis; B cell homeostasis; cellular response to DNA damage stimulus; establishment of vesicle localization; negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway; positive regulation of gene expression; positive regulation of I-kappaB kinase/NF-kappaB signaling; positive regulation of macroautophagy; positive regulation of NF-kappaB transcription factor activity; positive regulation of transcription by RNA polymerase II
Reference #:  O88522 (UniProtKB)
Alt. Names/Synonyms: 1110037D23Rik; AI848108; AI851264; AW124339; I-kappa-B kinase subunit gamma; IkB kinase subunit gamma; IkB kinase-associated protein 1; Ikbkg; IKK-gamma; IKK[g]; IKKAP1; IKKG; inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma; inhibitor of kappaB kinase gamma; Inhibitor of nuclear factor kappa-B kinase subunit gamma; mFIP-3; NEMO; NF-kappa-B essential modifier; NF-kappa-B essential modulator; OTTMUSP00000021358; OTTMUSP00000021360; OTTMUSP00000021361
Gene Symbols: Ikbkg
Molecular weight: 47,972 Da
Basal Isoelectric point: 5.61  Predict pI for various phosphorylation states
CST Pathways:  Apoptosis Regulation  |  B Cell Receptor Signaling  |  Death Receptor Signaling  |  Inhibition of Apoptosis  |  Insulin Receptor Signaling  |  NF-kB Signaling  |  T Cell Receptor Signaling  |  Toll-Like Receptor Signaling
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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Protein Structure Not Found.

Cross-references to other databases:  STRING  |  Reactome  |  BioGPS  |  Pfam  |  RCSB PDB  |  Phospho3D  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene