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IKKG
Regulatory subunit of the IKK core complex which phosphorylates inhibitors of NF-kappa-B thus leading to the dissociation of the inhibitor/NF-kappa-B complex and ultimately the degradation of the inhibitor. Its binding to scaffolding polyubiquitin seems to play a role in IKK activation by multiple signaling receptor pathways. However, the specific type of polyubiquitin recognized upon cell stimulation (either 'Lys-63'-linked or linear polyubiquitin) and its functional importance is reported conflictingly. Also considered to be a mediator for TAX activation of NF-kappa-B. Could be implicated in NF-kappa-B-mediated protection from cytokine toxicity. Essential for viral activation of IRF3. Involved in TLR3- and IFIH1-mediated antiviral innate response; this function requires 'Lys-27'-linked polyubiquitination. Heart, brain, placenta, lung, liver, skeletal muscle, kidney and pancreas. 3 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
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| Protein type: Adaptor/scaffold; Protein kinase, regulatory subunit |
| Chromosomal Location of human Ortholog: Xq28 |
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Cellular Component:
cytoplasm; cytosol; IkappaB kinase complex; mitotic spindle; nucleoplasm; nucleus; protein-containing complex; spindle pole; ubiquitin ligase complex
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Molecular Function:
identical protein binding; K63-linked polyubiquitin modification-dependent protein binding; linear polyubiquitin binding; metal ion binding; protein binding; protein domain specific binding; protein heterodimerization activity; protein homodimerization activity; transferrin receptor binding; ubiquitin protein ligase binding
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Biological Process:
anoikis; apoptotic process; DNA damage response; establishment of vesicle localization; I-kappaB kinase/NF-kappaB signaling; immune response; inflammatory response; innate immune response; negative regulation of neuron death; positive regulation of I-kappaB kinase/NF-kappaB signaling; positive regulation of macroautophagy; positive regulation of NF-kappaB transcription factor activity; positive regulation of T cell receptor signaling pathway; positive regulation of transcription by RNA polymerase II; protein-containing complex assembly; response to virus; T cell receptor signaling pathway
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Disease: Autoinflammatory Disease, Systemic, X-linked; Ectodermal Dysplasia, Hypohidrotic, With Immune Deficiency; Immunodeficiency 33; Incontinentia Pigmenti
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Reference #:
Q9Y6K9
(UniProtKB)
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Alt. Names/Synonyms: AMCBX1; EDAID1; FIP-3; FIP3; Fip3p; I-kappa-B kinase subunit gamma; IkB kinase gamma subunit; IkB kinase subunit gamma; IkB kinase-associated protein 1; IKBKG; IKK-gamma; IKKAP1; IKKG; IMD33; incontinentia pigmenti; inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma; inhibitor of nuclear factor kappa B kinase regulatory subunit gamma; inhibitor of nuclear factor kappa B kinase subunit gamma; Inhibitor of nuclear factor kappa-B kinase subunit gamma; IP; IP1; IP2; IPD2; NEMO; NF-kappa-B essential modifier; NF-kappa-B essential modulator; NFkappaB essential modulator; ZC2HC9
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Gene Symbols: IKBKG
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Molecular weight:
48,198 Da
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Basal Isoelectric point:
5.56
Predict pI for various phosphorylation states
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CST Pathways:
Apoptosis Regulation
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B Cell Receptor Signaling
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Death Receptor Signaling
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Inhibition of Apoptosis
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Insulin Receptor Signaling
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NF-kB Signaling
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T Cell Receptor Signaling
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Toll-Like Receptor Signaling
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Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology®
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