IKKG Regulatory subunit of the IKK core complex which phosphorylates inhibitors of NF-kappa-B thus leading to the dissociation of the inhibitor/NF-kappa-B complex and ultimately the degradation of the inhibitor. Its binding to scaffolding polyubiquitin seems to play a role in IKK activation by multiple signaling receptor pathways. However, the specific type of polyubiquitin recognized upon cell stimulation (either 'Lys-63'-linked or linear polyubiquitin) and its functional importance is reported conflictingly. Also considered to be a mediator for TAX activation of NF-kappa-B. Could be implicated in NF-kappa-B-mediated protection from cytokine toxicity. Essential for viral activation of IRF3. Involved in TLR3- and IFIH1-mediated antiviral innate response; this function requires 'Lys-27'-linked polyubiquitination. Heart, brain, placenta, lung, liver, skeletal muscle, kidney and pancreas. 3 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Adaptor/scaffold; Protein kinase, regulatory subunit
Chromosomal Location of Human Ortholog: Xq28
Cellular Component:  cytoplasm; cytosol; IkappaB kinase complex; mitotic spindle; nucleoplasm; nucleus; spindle pole; ubiquitin ligase complex
Molecular Function:  identical protein binding; linear polyubiquitin binding; metal ion binding; peroxisome proliferator activated receptor binding; protein binding; protein domain specific binding; protein heterodimerization activity; protein homodimerization activity; ubiquitin protein ligase binding
Biological Process:  activation of MAPK activity; anoikis; antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent; apoptotic process; cellular response to DNA damage stimulus; establishment of vesicle localization; Fc-epsilon receptor signaling pathway; I-kappaB kinase/NF-kappaB signaling; immune response; inflammatory response; innate immune response; interleukin-1-mediated signaling pathway; JNK cascade; MyD88-independent toll-like receptor signaling pathway; negative regulation of neuron death; nucleotide-binding oligomerization domain containing signaling pathway; positive regulation of I-kappaB kinase/NF-kappaB signaling; positive regulation of macroautophagy; positive regulation of NF-kappaB transcription factor activity; positive regulation of transcription by RNA polymerase II; protein deubiquitination; regulation of tumor necrosis factor-mediated signaling pathway; response to virus; stimulatory C-type lectin receptor signaling pathway; stress-activated MAPK cascade; T cell receptor signaling pathway; TRIF-dependent toll-like receptor signaling pathway; viral process
Disease: Ectodermal Dysplasia, Hypohidrotic, With Immune Deficiency; Immunodeficiency 33; Incontinentia Pigmenti
Reference #:  Q9Y6K9 (UniProtKB)
Alt. Names/Synonyms: AMCBX1; EDAID1; FIP-3; FIP3; Fip3p; I-kappa-B kinase subunit gamma; IkB kinase gamma subunit; IkB kinase subunit gamma; IkB kinase-associated protein 1; IKBKG; IKK-gamma; IKKAP1; IKKG; IMD33; incontinentia pigmenti; inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma; inhibitor of nuclear factor kappa B kinase regulatory subunit gamma; inhibitor of nuclear factor kappa B kinase subunit gamma; Inhibitor of nuclear factor kappa-B kinase subunit gamma; IP; IP1; IP2; IPD2; NEMO; NF-kappa-B essential modifier; NF-kappa-B essential modulator; NFkappaB essential modulator; ZC2HC9
Gene Symbols: IKBKG
Molecular weight: 48,198 Da
Basal Isoelectric point: 5.56  Predict pI for various phosphorylation states
CST Pathways:  Apoptosis Regulation  |  B Cell Receptor Signaling  |  Death Receptor Signaling  |  Inhibition of Apoptosis  |  Insulin Receptor Signaling  |  NF-kB Signaling  |  T Cell Receptor Signaling  |  Toll-Like Receptor Signaling
Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology® Total Proteins
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Protein Structure Not Found.

Cross-references to other databases:  STRING  |  cBioPortal  |  Wikipedia  |  Reactome  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  RCSB PDB  |  Phospho3D  |  Phospho.ELM  |  NetworKIN  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene