NPW
Plays a regulatory role in the organization of neuroendocrine signals accessing the anterior pituitary gland. Stimulates water drinking and food intake. May play a role in the hypothalamic response to stress. NPW23 activates GPR7 and GPR8 more efficiently than NPW30. Belongs to the neuropeptide B/W family. Detected at high levels in the substantia nigra, fetal kidney and trachea; at lower levels in testis, uterus, ovary and placenta. Not detectable in many regions of the central nervous system. Also detected at high levels in lymphoblastic leukemia and colorectal adenocarcinoma. Note: This description may include information from UniProtKB.
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Protein type: Secreted; Secreted, signal peptide |
Chromosomal Location of human Ortholog: 16p13.3 |
Cellular Component:
extracellular region
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Molecular Function:
G protein-coupled receptor binding; protein binding
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Biological Process:
feeding behavior; G protein-coupled receptor signaling pathway; neuropeptide signaling pathway
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Reference #:
Q8N729
(UniProtKB)
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Alt. Names/Synonyms: hL8; hL8C; hPPL8; L8; L8C; Neuropeptide W; Neuropeptide W-23; Neuropeptide W-30; NPW; NPW23; NPW30; PPL8; PPNPW; prepro-neuropeptide W; Preproprotein L8
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Gene Symbols: NPW
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Molecular weight:
18,048 Da
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Basal Isoelectric point:
11.62
Predict pI for various phosphorylation states
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