GRINL1A Isoform 1 appears to be a stable component of the Pol II(G) complex form of RNA polymerase II (Pol II). Pol II synthesizes mRNA precursors and many functional non-coding RNAs and is the central component of the basal RNA polymerase II transcription machinery. Isoform 1 may play a role in the Mediator complex-dependent regulation of transcription activation. Isoform 1 acts in vitro as a negative regulator of transcriptional activation; this repression is relieved by the Mediator complex, which restores Pol II(G) activator-dependent transcription to a level equivalent to that of Pol II. Belongs to the GRINL1 family. Detected in adult an fetal brain. Detected in heart, kidney, skeletal muscle, small intestine, lung, prostate and testis. 6 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Channel, ligand-gated; Nuclear envelope; Transferase
Chromosomal Location of Human Ortholog: 9 D|9 39.85 cM
Cellular Component:  neuronal cell body; nuclear envelope; nucleus; RNA polymerase II, holoenzyme
Molecular Function:  DNA-directed 5'-3' RNA polymerase activity
Biological Process:  intracellular signal transduction; maintenance of ER location
Reference #:  Q6P6I6 (UniProtKB)
Alt. Names/Synonyms: AA407243; AA408799; AI303746; AW553238; D9Wsu138e; DNA-directed RNA polymerase II subunit GRINL1A; glutamate receptor, ionotropic, N-methyl D-aspartate-like 1A; Glutamate receptor-like protein 1A; Grinl1a; GRL1A; KIAA4185; mKIAA4185; Protein GRINL1A
Gene Symbols: Grinl1a
Molecular weight: 41,237 Da
Basal Isoelectric point: 6.11  Predict pI for various phosphorylation states
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Protein Structure Not Found.

Cross-references to other databases:  STRING  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene