MAST2 Appears to link the dystrophin/utrophin network with microtubule filaments via the syntrophins. Phosphorylation of DMD or UTRN may modulate their affinities for associated proteins. Functions in a multi-protein complex in spermatid maturation. Regulates lipopolysaccharide-induced IL-12 synthesis in macrophages by forming a complex with TRAF6, resulting in the inhibition of TRAF6 NF-kappa-B activation. Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. Abundant in the testis. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: AGC group; EC; Kinase, protein; MAST family; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor)
Chromosomal Location of human Ortholog: 1p34.1
Cellular Component:  cytoplasm; plasma membrane
Molecular Function:  ATP binding; magnesium ion binding; phosphatase binding; protein binding
Biological Process:  protein phosphorylation; regulation of interleukin-12 biosynthetic process; spermatid differentiation
Reference #:  Q6P0Q8 (UniProtKB)
Alt. Names/Synonyms: FLJ39200; KIAA0807; MAST2; MAST205; microtubule associated serine/threonine kinase 2; microtubule associated testis specific serine/threonine protein kinase; Microtubule-associated serine/threonine-protein kinase 2; MTSSK; RP4-533D7.1
Gene Symbols: MAST2
Molecular weight: 196,436 Da
Basal Isoelectric point: 8.41  Predict pI for various phosphorylation states
Select Structure to View Below


Protein Structure Not Found.

Cross-references to other databases:  AlphaFold  |  STRING  |  cBioPortal  |  CCLE  |  Wikipedia  |  neXtProt  |  Protein Atlas  |  BioGPS  |  KinBase  |  Pfam  |  RCSB PDB  |  ENZYME  |  Phospho3D  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene