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SLC4A9
Electroneutral Cl-/HCO3- antiporter that favors chloride ion entry and efflux of hydrogencarbonate and sodium ion across the basolateral membrane and may participate in salivary secretion. Also mediates Cl-/HCO3- exchange activity in the presence of K+ as well as Cs+, Li+, and Rb+. Does not contribute to Cl-/HCO3- exchanger in the apical membrane of the upper villous epithelium. 4 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
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| Protein type: Membrane protein, integral; Membrane protein, multi-pass; Transporter; Transporter, SLC family |
| Chromosomal Location of human Ortholog: 5q31.3 |
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Cellular Component:
apical part of cell; basolateral plasma membrane; plasma membrane
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Molecular Function:
chloride:bicarbonate antiporter activity; sodium,bicarbonate:chloride antiporter activity; sodium:bicarbonate symporter activity
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Biological Process:
bicarbonate transport; chloride transmembrane transport; regulation of intracellular pH; saliva secretion; sodium ion transmembrane transport; transmembrane transport
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Reference #:
Q96Q91
(UniProtKB)
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Alt. Names/Synonyms: AE 4; AE4; Anion exchange protein 4; Anion exchanger 4; B3A4; SBC5; SLC4A9; Sodium bicarbonate cotransporter 5; Solute carrier family 4 member 9; solute carrier family 4, sodium bicarbonate cotransporter, member 9; solute carrier family 4, sodium bicarbonate cotransporter-like, member 9
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Gene Symbols: SLC4A9
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Molecular weight:
108,248 Da
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Basal Isoelectric point:
6.66
Predict pI for various phosphorylation states
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