NDR1 Negative regulator of MAP3K1/2 signaling. Converts MAP3K2 from its phosphorylated form to its non-phosphorylated form and inhibits autophosphorylation of MAP3K2. Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. Ubiquitously expressed with highest levels observed in peripheral blood leukocytes. Note: This description may include information from UniProtKB.
Protein type: AGC group; EC 2.7.11.1; Kinase, protein; NDR family; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor)
Chromosomal Location of Human Ortholog: 17|17 A3.3
Cellular Component:  cytoplasm; cytosol; nucleus
Molecular Function:  ATP binding; kinase activity; magnesium ion binding; metal ion binding; mitogen-activated protein kinase kinase kinase binding; nucleotide binding; protein binding; protein kinase activity; protein serine/threonine kinase activity; transferase activity
Biological Process:  cellular protein modification process; intracellular signal transduction; negative regulation of MAP kinase activity; peptidyl-serine phosphorylation; phosphorylation; protein phosphorylation
Reference #:  Q91VJ4 (UniProtKB)
Alt. Names/Synonyms: 5830476G13Rik; 9530097A09Rik; AA617404; Ndr1; NDR1 protein kinase; Nuclear Dbf2-related kinase 1; serine/threonine kinase 38; Serine/threonine-protein kinase 38; Stk38
Gene Symbols: Stk38
Molecular weight: 54,174 Da
Basal Isoelectric point: 6.91  Predict pI for various phosphorylation states
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NDR1

Protein Structure Not Found.


Cross-references to other databases:  STRING  |  BioGPS  |  KinBase  |  Pfam  |  ENZYME  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene