P2Y12 Receptor for ADP and ATP coupled to G-proteins that inhibit the adenylyl cyclase second messenger system. Not activated by UDP and UTP. Required for normal platelet aggregation and blood coagulation. Belongs to the G-protein coupled receptor 1 family. Highly expressed in the platelets, lower levels in the brain. Lowest levels in the lung, appendix, pituitary and adrenal gland. Expressed in the spinal cord and in the fetal brain. Note: This description may include information from UniProtKB.
Protein type: GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Mitochondrial; Receptor, GPCR
Chromosomal Location of human Ortholog: 3q25.1
Cellular Component:  basal plasma membrane; caveola; cell; cell body membrane; cell projection membrane; external side of plasma membrane; integral component of membrane; intrinsic component of membrane; mitochondrion; plasma membrane
Molecular Function:  ADP receptor activity; G protein-coupled adenosine receptor activity; guanyl-nucleotide exchange factor activity
Biological Process:  activation of phospholipase C activity; adenosine receptor signaling pathway; adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway; calcium ion transmembrane transport; calcium-mediated signaling; calcium-mediated signaling using extracellular calcium source; cell projection organization; cellular response to ATP; cytosolic calcium signaling involved in initiation of cell movement in glial-mediated radial cell migration; G protein-coupled purinergic nucleotide receptor signaling pathway; G protein-coupled receptor signaling pathway; hemostasis; lamellipodium assembly; microglial cell migration; negative regulation of cell differentiation; negative regulation of norepinephrine secretion; phospholipase C-activating G protein-coupled receptor signaling pathway; platelet aggregation; positive regulation of cell adhesion mediated by integrin; positive regulation of chemotaxis; positive regulation of integrin activation by cell surface receptor linked signal transduction; positive regulation of ion transport; positive regulation of microglial cell migration; positive regulation of phosphatidylinositol 3-kinase activity; positive regulation of protein kinase B signaling; positive regulation of ruffle assembly; potassium ion transmembrane transport; protein kinase B signaling; regulation of calcium ion transport; regulation of chemotaxis; regulation of microglial cell migration; response to axon injury; substrate-dependent cell migration, cell extension; visual system development
Disease: Bleeding Disorder, Platelet-type, 8
Reference #:  Q9H244 (UniProtKB)
Alt. Names/Synonyms: ADP-glucose receptor; ADPG-R; BDPLT8; G-protein coupled receptor SP1999; Gi-coupled ADP receptor HORK3; HORK3; P2RY12; P2T(AC); P2Y purinoceptor 12; P2Y(12)R; P2Y(AC); P2Y(ADP); P2Y(cyc); P2Y12; P2Y12 platelet ADP receptor; purinergic receptor P2RY12; purinergic receptor P2Y, G-protein coupled, 12; purinergic receptor P2Y12; putative G-protein coupled receptor; SP1999
Gene Symbols: P2RY12
Molecular weight: 39,439 Da
Basal Isoelectric point: 9.6  Predict pI for various phosphorylation states
Select Structure to View Below


Protein Structure Not Found.

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