KCNIP4 Regulatory subunit of Kv4/D (Shal)-type voltage-gated rapidly inactivating A-type potassium channels. Modulates KCND2 channel density, inactivation kinetics and rate of recovery from inactivation in a calcium-dependent and isoform-specific manner. Modulates KCND3/Kv4.3 currents. Isoform 4 does not increase KCND2 expression at the cell membrane. Isoform 4 retains KCND3 in the endoplasmic reticulum and negatively regulates its expression at the cell membrane. Belongs to the recoverin family. Predominantly expressed in brain. 5 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Chromosomal Location of human Ortholog: 4p15.31-p15.2
Cellular Component:  cytoplasm; cytosol; dendrite; endoplasmic reticulum; neuronal cell body; peroxisome; plasma membrane; voltage-gated potassium channel complex
Molecular Function:  calcium ion binding; potassium channel activity; potassium channel regulator activity; protein binding; voltage-gated monoatomic ion channel activity
Biological Process:  potassium ion transmembrane transport; protein localization to plasma membrane; regulation of potassium ion transmembrane transport
Reference #:  Q6PIL6 (UniProtKB)
Alt. Names/Synonyms: A-type potassium channel modulatory protein 4; CALP; Calsenilin-like protein; KCHIP4; KCIP4; KCNIP4; Kv channel interacting protein 4; Kv channel-interacting protein 4; MGC44947; potassium channel interacting protein 4; Potassium channel-interacting protein 4; potassium voltage-gated channel interacting protein 4
Gene Symbols: KCNIP4
Molecular weight: 28,729 Da
Basal Isoelectric point: 5.12  Predict pI for various phosphorylation states
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KCNIP4

Protein Structure Not Found.


Cross-references to other databases:  AlphaFold  |  STRING  |  cBioPortal  |  Wikipedia  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  InnateDB  |  Ensembl Protein